LARVICIDE AND ANTIFUNGAL ACTIVITIES OF SARSAPARILLA (SMILAX LARVATA) EXTRACTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 1
Abstract
Objective: This study aimed to investigate the toxicity, antimicrobial and larvicide activities of Smilax larvata Griseb. (Smilacaceae) extracts.Methods: Toxicity evaluation was performed by testing brine shrimp lethality. The presence of saponins in S. larvata extracts was investigated using a hemolysis test. For antimicrobial investigation, S. larvata extracts were submitted to disk diffusion assay, and larvicide activity was evaluated using a larvicidal assay against Aedes aegypti larvae.Results: S. larvata extracts were not toxic to the shrimp and in the hemolysis test, only hexane, chloroform and ethanolic extracts showed significant hemolytic activity at 1000 µg. mL-1 (100%, 59% and 40% respectively). The crude ethanolic extract presented larvicide effect on third instar of Aedes aegypti larvae with LC50 = 225 µg. mL-1 and LC90 = 350 µg. mL-1, and showed antifungal activity against C. albicans.Conclusion: These results indicate that S. larvata extracts are a potential source of antifungal agents and new eco-friendly larvicide compounds.Â
Authors and Affiliations
Beatriz Cristina Konopatzki Hirota, Cristiane Da Silva Paula Oliveira, Francis José Zortéa Merino, Maria Christina Dos Santos Verdam, Cristiane Bezerra Da Silva, Fabio Seigi Murakami, Obdulio Gomes Miguel, Marilis Dallarmi Miguel
Keywords
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