Lead Acetate Induced Cerebral Tissue Damage; The Effect of Phoenix dactylifera Pits Extract
Journal Title: European Journal of Medicinal Plants - Year 2017, Vol 21, Issue 2
Abstract
This study investigates effect of Phoenix dactylifera pits extract (PdPE) on Lead acetate induced cerebral tissue damage. Wistar rats of average weight 150 g were divided into seven groups of six animals each. GRPI animals received distilled water only, GRPII received 60 mg/kg Lead acetate 5 times a week for 3 weeks then distilled water only for ten days (Negative control), GRPIII and GRPIV (treatment groups) received 60 mg/kg Lead acetate 5 times a week for 3 weeks then treated with 150 mg/kg PdPE and 300 mg/kg PdPE respectively for 10 days, Group V and Group VI (protective groups) received 150 mg/kg PdPE and 300 mg/kg PdPE respectively for 10 days then 60 mg/kg Lead acetate 5 times a week for 3weeks, while GRPVII animals received 60 mg/kg Lead acetate 5 times a week for 3 weeks then treated with 25 mg/kg Dimercaptosuccinic acid (DMSA) alone 4 times a week then distilled water for 3 days. Lead acetate induced cerebral tissue damage was evident from depleted reduced-glutathione and lipid peroxidation as shown by elevated malondialdehyde and nitrite concentration. Histological examination of the cerebral tissue showed congestion of the meningeal vessels and cellular infiltration. Malondialdehyde and nitrite were significantly reduced by 300 mg/kg PdPE (P<0.03). 300 mg/kg PdPE protective and treatment groups and 25 mg/kg DMSA ameliorates antioxidant depletion and showed significant protective effect against cerebral tissue damage. Memory assessment showed that 300 mg/kg PdPE and 25 mg/kg DMSA treatment significantly alleviate memory impairment induced by Lead acetate. Results from the study indicate that PdPE has the ability to alleviate lead acetate induced cerebral tissue damage in rats. PdPE may exert its protective and therapeutic effect against lead-induced cerebral damage possibly through its antioxidant mechanisms and due to the presence of membrane protecting unsaturated fatty acids.
Authors and Affiliations
Isei Michael Osawe Kayode, Iwalewa Ezekiel Olugbenga
Keywords
Related Articles
- EP ID EP327252
- DOI 10.9734/EJMP/2017/37302
- Views 76
- Downloads 0
The Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats
Aim: The aim of this study was to examine the effect of ethanolic extract of coriander leaves as a potent in vivo antioxidant agent in an effort of finding possible sources of antioxidants for future use in food and phar...
The Effects of Zinc Application and Cutting on Growth, Herb, Essential Oil and Flavonoids in Three Medicinal Lamiaceae Plants
Aims: The objective of this study was to investigate the effect of zinc on growth, fresh herb, essential oil and flavonoids content of Dracocephalum moldavica, Hyssopus officinalis and Salvia officinalis plants at two su...
Antifungal and Cytotoxicity Activity of Plants Used as Herbal Teas in Tanzania
Aim: The current study was designed to determine antifungal and cytotoxicity activity of Rhus vulgaris, Sphaeranthus bullatus, Osyris lanceolata, Ocimum gratissimum, Cymbopogon citratus, Acacia nilotica and Ty...
Phytochemical and Antimicrobial Evaluation of Leaf-extracts of Pterocarpus santalinoides
Aim: This study was undertaken to examine the phytochemical constituents and antimicrobial activity of leaf-extracts of Pterocarpus santalinoides, a plant with wide application in Igede people’s traditional medicine agai...
Cytotoxic, Thrombolytic and Membrane Stabilizing Activities of Swietenia mahagoni (L.) Jacq. Flower Extract
Aims: To investigate cytotoxic, thrombolytic and membrane stabilizing activities of methanol extract and its different Kupchan partitionates of flowers of Swietenia mahagoni. Study Design: Evaluation of cytotoxic activit...