LEFT VENTRICULAR DYSFUNCTION IN COPD WITH OR WITHOUT COR PULMONALE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 2
Abstract
BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) is a disease state characterised by the presence of airflow obstruction due to chronic bronchitis or emphysema, which is progressive and partially reversible. Right ventricular failure (cor pulmonale) is a well-known complication of COPD. But, it also involves left ventricle leading to systolic as well as diastolic dysfunction, which maybe present with associated RV failure and also as a separate entity. Diastolic dysfunction is due to defective filling of the left ventricle because of the hyperinflated lung. On the other hand, systolic dysfunction maybe secondary to RV failure due to the effects of hypoxia in the cardiac muscle fibres as a part of the systemic hypoxaemia or it may be due to the effects of the circulatory inflammatory mediators leading to atherosclerosis and ischaemia of cardiac muscles. MATERIALS AND METHODS It was a prospective study of 100 patients of COPD classified according to GOLD criteria with or without cor pulmonale admitted to our hospital in the period of January 2014 to October 2015 meeting our inclusion and exclusion criteria. Investigations like chest x-ray, spirometry, 2D-echocardiography and electrocardiography were done and data was collected. Data were pooled and interpreted using standard statistical methods. RESULTS Prevalence of COPD was common after middle age, the peak being around 5th and 6 th decade of life without much gender inequality. Cor pulmonale was found in 65% patients of COPD, of which more number were in the severe COPD. LV systolic dysfunction was found in 44% of all COPD patients and LV diastolic dysfunction was found in 59% of cases. LV diastolic dysfunction was found in 64% and LV systolic dysfunction was found in 49% of patients of COPD with cor pulmonale. LV systolic dysfunction was found in 62% of COPD patients who showed a resting hypoxaemia (SpO2 <90%). CONCLUSION In our study of 100 COPD patients, we found LV diastolic dysfunction in more than half of patients of moderate and severe stages of COPD. LV systolic dysfunction was found in more than one-third of the patients of COPD. So, though cor pulmonale is a frequent complication of COPD, assessment of LV function and diagnosing LV dysfunction early in the course is equally important. Hence, we strongly recommend for routine echocardiography in all patients of COPD especially of severe grades for evaluation of LV function, which will reduce the morbidity and mortality and also can improve the quality of life.
Authors and Affiliations
Uma Shankar Mishra, Chandan Kumar Gantayat
Keywords
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- EP ID EP448647
- DOI 10.18410/jebmh/2018/41
- Views 61
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