Left Ventricular Remodeling Predictors in Patients with Obesity of Varying Severity
Journal Title: Український журнал медицини, біології та спорту - Year 2017, Vol 8, Issue 6
Abstract
The purpose of the study was to examine clinical and anthropometric predictors of left ventricular hypertrophy in patients with isolated obesity of different stages of severity. Materials and methods. 63 people with obesity and overweight, who formed the main group, were examined. The control group included 22 people with normal weight. All participants of the study were subjected to a general clinical examination with a mandatory measurement of the waist and hip circumference, weight and height, transthoracic echocardiography. The calculations were performed using SPSS software (version 22.0; SPSS, Chicago, IL). Results. It was found out that systolic function in all subjects was normal and did not significantly differ from the control group. Patients with severe obesity significantly higher thickness of interventricular septum, thickness of the posterior wall of the left ventricle, left ventricular mass index (g/m2) and left ventricular mass index (g/PPTm2). Left ventricular hypertrophy was established only in 3 patients from group with severe obesity. All patients had a concentric remodeling of left ventricular. There were no significant differences in patients with high body weight. It was estimated that patients with abdominal obesity in comparison with the group of patients with other types of obesity had significantly higher thickness of the posterior wall of the left ventricle ((0,95 ± 0,11) cm versus (0,83 ± 0,10) cm), thickness of interventricular septum ((0,89 ± 0,12) cm vs. (0,72 ± 0,1)) and left ventricular mass index ((82,13 ± 7,12) g / PPTm2 vs. (79,6 ± 8,12) g / PPTm2). According to correlation analysis results, a positive correlation was found between BMI and thickness of the posterior wall of the left ventricle (r = 0,422, p = 0,05), thickness of interventricular septum (r = 0,38, p = 0,001) and left ventricular mass index (m2/PPT) (r = 0,384, p < 0,05). Weak positive correlation between waist circumference and left ventricular mass index was established (m2 / PPT) (r = 0,211, p = 0,03). Based on the literature data, potential predictors of the increase of left ventricular mass and left ventricular mass index (g/PPTm2) were selected: among the anamnestic factors – age; among clinical factors – average systolic arterial pressure, among anthropometric factors – weight, BMI, waist circumference, circle hips, waist circumference/circle hips ratio. These variables were tested in a multi-factor regression model. The final regression model demonstrated that the age and waist circumference/circle hips ratio were an independent predictor of changes in left ventricular mass index (g/m2) and left ventricular mass index (g/PPTm2) in obese patients without cardiovascular disease. Conclusions. Reliable structural and functional changes of the left ventricle in patients with isolated moderate and severe obesity were established. Left ventricular hypertrophy was diagnosed only in 3 patients with the third degree of obesity. All of them had a concentric remodeling of the myocardium. According to regression analysis, the age and waist circumference/circle hips ratio were independent predictors of changes in left ventricular mass index (g/m2) and left ventricular mass index (g/PPTm2) in obese patients without cardiovascular disease.
Authors and Affiliations
I. Andreieva, O. Tokarenko, D. Myrnyi
Keywords
Related Articles
- EP ID EP275168
- DOI -
- Views 85
- Downloads 0
The Serum Marker Enzymes Activity and Metabolic Connective Tissue Disorders in Patients on Early Stages of Osteoarthritis of the Knee Joints
The article deals with the determination of the marker enzymes activity (hyaluronidase, alkaline phosphatase and its bone isoenzymes), serum and urine concentrations of fibronectin, uric acid and uric acid in patients w...
УСТРАНЕНИЕ СТУПЕНЧАТОГО УСТУПА В ИЗОГНУТОМ КОРНЕВОМ КАНАЛЕ ПРИ ПОВТОРНОМ ЭНДОДОНТИЧЕСКОМ ЛЕЧЕНИИ ЗУБОВ, РАНЕЕ ОБТУРИРОВАННЫХ РЕЗОРЦИН-ФОРМАЛИНОВЫМ МЕТОДОМ
Создание ступенчатого уступа при эндодонтическом лечении является ятрогенным осложнением. Под уступом понимают искусственно сформированное отклонения от естественной траектории корневого канала без сообщения с периодонто...
АНАЛИЗ СЛУЧАЯ ВЕДЕНИЯ ПАЦИЕНТА С ЭОЗИНОФИЛЬНЫМ ГРАНУЛЕМАТОЗОМ С ПОЛИАНГИИТОМ
Эозинофильний гранулематоз с полиангиитом входит в список так называемых редких или орфанных заболеваний в соответствии с приказом МЗ Украины от 27.10.2014 № 778. Нашей целью было на основе литературных данных и своего о...
Ultrastructural Changes in the Retina during the Process of Paclitaxel-Induced Retinotoxicity Correction using Antioxidant Drug
Paclitaxel is widely used in the antiblastic treatment schemes, although with side effects observed. Last ones can include vision defects, whose pathogenesis is determined by a few factors: the structural changes of the...
СТАН ЕПІДЕМІОЛОГІЧНОЇ СИТУАЦІЇ З ВІЛ-ІНФЕКЦІЇ/СНІДУ В ЖИТОМИРСЬКІЙ ОБЛАСТІ ЗА 2009-2016 РОКИ
У статті висвітлено аналіз епідемічної ситуації з ВІЛ/СНІД у Житомирській області за результатами оцінки регіональних програм з протидії ВІЛінфекції/СНІДу за 2009–2016 роки. В області простежується залучення до епідемічн...