Leptomeningeal Carcinomatosis Originated from Breast Cancer
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2015, Vol 5, Issue 3
Abstract
Malignant melanoma, breast cancer and lung cancer are the most causative malignancies of leptomeningeal carsinomatosis (LC). A LC case that was previously diagnosed as tuberculosis meningitis, is presented here to emphasize the importance of maintaining a broad differential diagnosis in patients applied to the hospital with meningeal irritation symptoms. A 35-year-old woman was suffering from a severe headache and photophobia. Physical examination revealed nuchal rigidity but Kernig’s and Brudzinski signs were negative. Cerebrospinal fluid (CSF) findings were 171 cells/mm3 (lymphocytic predominance), elevated protein levels, decreased glucose. Atypical cells were detected in CSF cytology. The result of breast biopsy was in accordance with breast lobular carcinoma nuclear grade III. LC, usually developes in patients who have a known primary malignancy. As it occured in our case; in up to 10%-20% of cases, however, symptoms caused by LC may emerge before the diagnosis of the primary tumor. It should remember that meningitis may not be always infectious originated. J Microbiol Infect Dis 2015;5(3): 133-136 Key words: leptomeningeal carcinomatosis, meningitis, cerebrospinal fluid cytology
Authors and Affiliations
Seniha Şenbayrak, Seyfi Özyürek, Orçun Barkay, Çiğdem Kuyumcu, Fügen Aker
Keywords
Related Articles
- EP ID EP111834
- DOI 10.5799/ahinjs.02.2015.03.0192
- Views 117
- Downloads 0
Ethionamide depolama sıcaklığının duyarlılık testine etkisi
Amaç: Ethionamide ısıya duyarlı yapısı nedeniyle, ilaç duyarlılık testinde (DST) ısının etkisini ve sıvı veya katı ortamdaki dayanıklılık durumunun araştırılması amaçlanmıştır. Yöntemler: Ethionamide çalışma solüsyonu v...
Diagnostic value of Cobas Amplicor MTB and Rotorgene Real Time PCR for tuberculous meningitis: A six-year retrospective study
Objective: Tuberculous meningitis (TBM) is the most severe and lethal form of tuberculosis (TB).Bacteriologic confirmation of TBM is difficult and slow. Therefore, most patients receive antituberculosis treatment based o...
Antimicrobial susceptibility, virulence factors and biofilm formation among Staphylococcus aureus isolates from hospital infections in Kerman, Iran
Objective: The aims of present study were to determine the antimicrobial susceptibility, virulence factors and biofilm formation among MRSA hospital isolates of Staphylococcus aureus. Methods: Thirty non-repetitive stra...
Yılan ısırığı olgularında yılan zehirinin serum bakır, çinko ve magnezyum seviyesi üzerine etkisi
Amaç: Yılan ısırıkları Türkiye’nin doğu ve güneydoğu bölgelerinde sık görülen önemli bir problemdir. Bu çalışmada yılan ısırığı vakalarında serum bakır (Cu), çinko (Zn) ve magnezyum (Mg) düzeylerindeki değişiklikler ara...
Preseptal and orbital cellulitis
Preseptal cellulitis (PC) is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC) is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. P...