Leptomeningeal Carcinomatosis Originated from Breast Cancer
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2015, Vol 5, Issue 3
Abstract
Malignant melanoma, breast cancer and lung cancer are the most causative malignancies of leptomeningeal carsinomatosis (LC). A LC case that was previously diagnosed as tuberculosis meningitis, is presented here to emphasize the importance of maintaining a broad differential diagnosis in patients applied to the hospital with meningeal irritation symptoms. A 35-year-old woman was suffering from a severe headache and photophobia. Physical examination revealed nuchal rigidity but Kernig’s and Brudzinski signs were negative. Cerebrospinal fluid (CSF) findings were 171 cells/mm3 (lymphocytic predominance), elevated protein levels, decreased glucose. Atypical cells were detected in CSF cytology. The result of breast biopsy was in accordance with breast lobular carcinoma nuclear grade III. LC, usually developes in patients who have a known primary malignancy. As it occured in our case; in up to 10%-20% of cases, however, symptoms caused by LC may emerge before the diagnosis of the primary tumor. It should remember that meningitis may not be always infectious originated. J Microbiol Infect Dis 2015;5(3): 133-136 Key words: leptomeningeal carcinomatosis, meningitis, cerebrospinal fluid cytology
Authors and Affiliations
Seniha Şenbayrak, Seyfi Özyürek, Orçun Barkay, Çiğdem Kuyumcu, Fügen Aker
Keywords
Related Articles
- EP ID EP111834
- DOI 10.5799/ahinjs.02.2015.03.0192
- Views 100
- Downloads 0
Investigation of Naturally Acquired Antibody to Haemophilus influenzae Type b Polysaccharide in China
In a word, although this investigation having relatively less scope, however, for public health policy makers we recommend a range which may lead to decrease the spread of Hib infection.
Prevalence of Staphylococci in Commercially Processed Food Products in Karachi-Pakistan
Objectives: This study was designed to determine the prevalence of Staphylococci, Staphylococcus aureus (S. aureus), and Methicillin Resistant S. aureus (MRSA) in commercially prepared food items that involve human handl...
Knowledge, Attitude and Pattern of Antibiotic Usage among Students of a Nigerian University
Objective: Antibiotic resistance is a major public health issue globally fueled largely by its misuse. Controlling this problem would require an understanding of the levels of awareness of the population towards antibiot...
Chronic osteomyelitis of skull associated with necrotic injury after trauma: A case report
A 32-year-old male came to the emergency room with a crescentric 4x11 cm tissue defect at the right temporo-parietal region. Brain tomography showed a tissue defect in the right parietal region but bone integrity was pre...
Impact of appropriate antimicrobial therapy on survival in patients with Acinetobacter baumannii-associated infections
Objective: To assess the impact of inappropriate antimicrobial treatment on the 30-day mortality in patients with Acinetobacter baumannii associated infections. Methods: 87 patients with nosocomial infections caused by...