LEUKOTRIENE B4 AND PROSTAGLANDIN E2 LEVELS IN PATIENTS WITH NSAID-GASTROPATHY AFTER PANTOPRAZOLE TREATMENT
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2017, Vol 49, Issue
Abstract
NSAIDs (nonsteroidal anti-infl ammatory drugs) are widely used for the prevention of cardiovascular diseases. However, depending on the dose and NSAIDs duration, there may be development of the stomach and duodenum mucosa lesions in the erosions form and ulceration even. Proton pump inhibitors (PPIs) are used to play the main role in preventing adverse effects of NSAIDs, which is called “gastrocytoprotection”. Leukotriene B4 and prostaglandin E2 are the most important factors involved in processes of the aggression and protection the stomach and duodenum mucous membrane. In physiological conditions, there is a balance between the production of its arachidonic acid derivatives. NSAIDs appointment in patients with cardiovascular disorders for the thrombosis and embolism prevention leads to cyclooxygenase inhibition by changing the balance between PgE2 and LTB4, in favor of the latter, with further NSAID-gastropathy development.
Authors and Affiliations
K. Kvit, E. Sklyarov, M. Mbarki
Keywords
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