Level of Chemerin and Anti-Müllerian Hormone in Egyptian Obese Women with Polycystic Ovarian Syndrome.
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 7
Abstract
<strong>Background: </strong>Chemerin is a newly discovered adipokine that regulates adipocyte development, metabolic function as well as immune function. Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that belongs to the transforming growth factor-beta family.<br /> <strong>Aim of the study</strong>: was to evaluate the serum levels of Chemerin and AMH in one trial to show their possible involvement in the pathogenesis of PCOS and their association with obesity.<br /> <strong>Subjects and methods: </strong>This study was performed on eighty subjects divided into 4 groups: Group I: 20 non-obese control (BMI< 30), Group II: 20 non-obese patient with polycystic ovarian syndrome (BMI< 30), Group III: 20 obese Control (BMI ≥ 30) and Group IV: 20 obese patient with PCOS (BMI ≥ 30). Serum levels of Chemerin and AMH were estimated by ELISA.<br /> <strong>Results: </strong>Results showed a significant increase in serum levels of <strong><em>Chemerin and AMH</em></strong> in (non-obese and obese) PCOS groups when compared to their controls. Results showed also a significant increase in the serum level of <strong><em>Chemerin </em></strong>in obese PCOS group when compared to non-obese PCOS group. While a significant decrease in serum level of <strong><em>AMH</em></strong> in obese PCOS group when compared to non-obese PCOS group. There were a significant positive correlation between <strong><em>Chemerin and</em></strong><strong><em> AMH </em></strong>in PCOS groups.<br /> <strong>Conclusion: </strong>Chemerin together with AMH may be used as a biomarker for early detection of PCO and Clinical parameters as Infertility and Hyper and rogenism in women with PCOS.<br /> <strong> </strong>
Authors and Affiliations
Eman Helal
Keywords
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