Level of Interleukin 8 and Alpha -1 Antitrypsin in CerebroSpinal Fuid of Iraqi Patient with Bacterial and Viral Meniningitis
Journal Title: IOSR Journals (IOSR Journal of Computer Engineering) - Year 2016, Vol 18, Issue 4
Abstract
Objective: Meningitis refers to inflammation of the leptomeninges, the connective tissue layers in closest proximity to the surface of the brain. Meningitis can be caused by bacteria, viruses, parasites, and fungi, as well as by non-infectious conditions, including inflammatory disorders. Interleuk-8 (IL-8) is produced predominantly by monocytes, but also by fibroblasts and endothelial cells. This chemokine may play a role in various inflammatory and infectious diseases. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase . Methods: Forty seven patients with meningitis disease admitted to Medical city hospital and Al- Kadimia Hospital between June –October /2012, Their age ranged between (11 days to 6.0 years). These patients were divided into group infected with viral and bacterial infections according to the laboratory finding of cells and biochemical tests and microbiology examination .A quantitative sandwich enzyme immunoassay technique was performed . Antibody specific for IL-8 has been pre-coated onto a microplate. Standards and samples arepipetted into the wells and any IL-8 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for IL-8 is added. Result: IL-8 concentrations were higher in both bacterial and viral meningitis demonstrating that this molecule may acts as a mediator in meningial inflammation. Alpha -1 Antitrypsin (A1AT) play a major role in laboratory investigations to differentiating viral and bacterial meningitis along with CSF cell count .The level of A1AT in the bacterial meningitis was higher than the level of viral meningiti.
Authors and Affiliations
Dr. Anmar O. Hatem FIBM
Keywords
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