Level of serum beta carotene and its association with lumbar osteophyte formation
Journal Title: Indian Journal of Orthopaedics Surgery - Year 2018, Vol 4, Issue 3
Abstract
Introduction Cause of chronic low back pain in persons over the age of 50 years include degenerative diseases like osteoarthritis of spine and spinal canal stenosis Osteoarthritis of spine is a degenerative process1930 identified radiologically by joint space reduction marginal osteophytes and subchondral sclerosis Nathan et al3 classified significantly osteophyte positive if more than SIX osteophytes are found from L1 L2 to L5 S1 vertebrae in the lumbar spine XraysSerum beta carotene is a carotenoid which has antioxidant effect3537 by increasing Glutathione levels in cells Normal serum beta carotene level ranges from 074 nmolml to 372 nmolsml Based on literature higher serum beta carotene levels are shown to halt the progression of many diseases including cardiac diseases 3839 and degenerative changes in knee joint But so far only a single study is available to corelate the levels of serum beta carotene and lumbar spine osteophytes Hence this study was doneMaterials and Methods This study was conducted at JIPMER Pondicherry from August 2015 to March 2017 It was conducted as OP procedure 153 patients of over 50 years of year who complained of low back pain of more than 3 months duration were selected Their personal history regarding alcohol drinking and smoking noted Radiographs of lumbar spine AP and lateral views were taken They were divided into osteophyte positive or negative as defined by Nathan3 These patients serum beta carotene levels were assessed The level of serum beta carotene and its relationship with lumbar spine osteophyte formation was analysedResults Females predominated study 67 of patients were osteophyte negative and 33 were positive 74 of osteophyte positive patients had serum beta carotene less than 07 nmolml and 26 had more than that But nearly all 98 of osteophyte negative had more than 07 nmolml of serum beta carotene showing that the lumbar osteophyte formation is inversely proportional to the level of serum beta carotene levels Our statistics also showed that there is a strong association between alcohol consumptions and smoking with lumbar osteophyte formationConclusion Our study showed that low serum beta carotene levels predisposed and increased lumbar osteophyte formation It also showed strong association between Alcohol consumption and Tobacco use with lumbar osteophyte formationKeywords Lumbar osteophyte Serum beta carotene Degenerative osteoarthritis Alcohol consumption Tobacco use Chronic low back pain
Authors and Affiliations
N Selvam, Raju Babu Rapeta
Keywords
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- EP ID EP476649
- DOI 10.18231/2395-1362.2018.0058
- Views 96
- Downloads 0
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