Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 2
Abstract
Introduction: Diabetes Mellitus (DM) is always a multifactorial metabolic disorder having a wide range of abnormalities in carbohydrate, lipid and protein metabolism. Dyslipidemia is a natural process of DM causing abnormal variations of different lipoproteins and it is one of the significant risk factors for Cardiovascular Disorder (CVD). There is a need to closely evaluate newer approaches in case of DM because even if dyslipidemia is treated, there is always a risk of CVDs in DM patients because of the hyperglycemia itself. So, lipid abnormalities should be assessed aggressively and treated as part of diabetes care. Apolipoprotein B100 (Apo B100), Apolipoprotein A1 (Apo A1) and Lipoprotein (a) {Lp(a)} are newer markers which are always welcome and necessary as many of the reported cases with normal conventional lipid profile have developed cardiac events. Aim: Study the correlation between glycemic control and the levels of Apo A1, Apo B100 and Lp(a). Materials and Methods : Total 56 patients of (DM) diagnosed on the basis of American Diabetic Association guidelines were recruited, out of which 28 were identified as uncontrolleddiabetic patients and remaining 28 as controlled-diabetics on the basis of Glycosylated HbA1c (HbA1c). The control group consisted of normal healthy 28 individuals. Apo B100, Apo A1 and Lp(a) along with traditional lipid profile, Fasting Blood Sugar (FBS) and HbA1c were estimated in all the subjects. Results: Apo B100/Apo A1 ratio and Lp(a) levels showed highly significant difference (p-value <0.001) between uncontrolled diabetics, controlled diabetics and healthy Controls. Apo B100/ Apo A1 ratio and Lp(a) showed significant positive correlations with HbA1c (r= 0.494, p <0.0001) and with each other. Conclusion: Apo B100/Apo A1 ratio and Lp(a) show a highly significant positive relationship with glucose tolerance of the patients as reflected in the HbA1c values. If proper glycemic control is maintained, the levels of Apo B100/Apo A1 ratio and Lp(a) can be controlled as reflected by the lower levels of these parameters observed in controlled diabetics in comparison to uncontrolled diabetics.
Authors and Affiliations
Vishwal Indravadan Patel, Kinjal Prahaladbhai Patel, Mayur Goradhanbhai Makadia, Aashna Darshanbhai Shah, Kaushik Salubhai Chaudhari, Haridas Neelakandan Nilayangode
Keywords
Related Articles
- EP ID EP331839
- DOI 10.7860/JCDR/2017/22741.9258
- Views 111
- Downloads 0
Physical Activity during Pregnancy and its Relationship with the Functional Status of Primiparous Women Six Weeks after Childbirth: A Cohort Study
ABSTRACT Introduction: The transition to motherhood is a major life event that affects all aspects of psychosocial functioning. Aim: The aim of this study was to determine the relationship between physical activity durin...
Anterior Space Maintainer Incorporating a Pontic Derived from a Strip Crown
Various designs of functional and aesthetic space maintainers have been used in the anterior region to replace missing upper primary anteriors. All of these had utilised pontics made of composite, acrylic or natural teet...
Concomitant Pulmonary Embolism and Acute Renal Failure in a Patient Undergoing Head Neck Surgery: A Case Report and Review of Literature
Surgical interventions for malignant neoplasms of the head and neck region bear a risk of general medical complications. Venous thromboembolism and pulmonary embolism is closely tied to patients suffering from carcinoma...
The Level of Professional Autonomy in Iranian Nurses
ABSTRACT Introduction: Professional autonomy plays an important role in nurses’ job satisfaction and the outcomes of patient care. A review of literature shows the presence of nurses’ dissatisfaction in regard to their p...
The Effect of Dialysate Temperature on Urea Reduction Ratio among Patients Undergoing Maintenance Haemodialysis: A Case Control Study
ABSTRACT Introduction: Lowering the dialysate temperature in Intradialytic Hypotension (IDH) prone Maintenance Haemodialysis (MHD) patients, offers better haemodynamic stability. Evidence is lacking relating the effects...