Levels of Interleukin‐18 in Saliva and Gingival Crevicular Fluid in Patients with Chronic Periodontitis and Healthy Subjects
Journal Title: Annual Research & Review in Biology - Year 2016, Vol 10, Issue 3
Abstract
Aims: Cytokines play a key role in the initiation and progression of chronic periodontitis. This study aimed to measure and compare the levels of Interleukin (IL)-18 in both saliva and gingival cervicular fluid (GCF) of patients with chronic periodontitis and healthy controls. Study Design: In this descriptive study we assessed the levels of IL-18 in unstimulated whole saliva and GCF samples among patients with chronic periodontitis and individuals with healthy periodontium. Place and Duration of Study: Department of periodontology and Department of biochemistry, Services Institute of Shahid Sadughi University of Medical Science, between May 2015 and Jan 2016. Methodology: Thirty two subjects were divided into two groups; 16 individuals with healthy periodontium and 16 patients with chronic periodontitis. GCF and saliva samples were obtained. The concentrations of IL-18 in GCF and saliva were determined using ELISAs. Results: There was no significant difference between the levels of IL-18 in saliva and GCF samples among the study groups (Respectively P= 0.44 and P= 0.38). Also, significantly different was not observed while comparing the IL-18 level of saliva with the IL-18 level of GCF in both healthy subjects (P= 0.8) and patients with chronic periodontitis (P= 0.61). Conclusion: Similar levels of IL-18 among study groups suggested that levels of IL-18 in saliva and GCF cannot be used as a predictable biomarker for early diagnosis of periodontal disease.
Authors and Affiliations
Zeinab Rezaei Esfahrood, Davood Zare, Javad Zavar Reza, Farzaneh Rahmanian
Keywords
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- EP ID EP351077
- DOI 10.9734/ARRB/2016/25982
- Views 72
- Downloads 0
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