Levels of Oxidized Low-Density Lipoprotein and High Sensitive C-Reactive Protein in Retinal Vascular Occlusions: A Pilot Study
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2014, Vol 1, Issue 1
Abstract
Background: Oxidized low-density lipoprotein (OX-LDL) is believed to be a key trigger factor in the genesis of atherosclerosis. It has been postulated that it can activate inflammatory mediators such as high sensitive C-reactive protein (hs-CRP), interleukin 6 (IL6), and tumour necrosis factor (TNF). These mediators have been demonstrated to have an atherogenic effect. Aims: This pilot study examined levels of OX-LDL and hs-CRP in patients with retinal vascular occlusive disorders. Methods: We enroled 7 patients with retinal vascular occlusions during a two-month period. A high sensitive CRP of greater than 3mg/l was considered significantly elevated and a median oxidised LDL value greater than 59 U/L was considered significantly elevated. Results: There were 4 cases of retinal vein occlusion, 1 case of amaurosis fugax, 1 case of cilioretinal artery occlusion and a case of cholesterol embolus in the retinal vasculature. Mean OX-LDL (55.6±21.1 U/L) was borderline, but within the normal range (<59 U/L) but hs-CRP (3.9±3.1 mg/l) were elevated compared to the normal range (0 -3 mg/l). Oxidized LDL was elevated in three patients (43%), and bordeline (between 55 and 59 U/L) in two patients (28%). No significant correlation was found between hs-CRP and OX-LDL values (Pearson’s correlation: r = 0.256; p = 0.456). Conclusion: This study is the first to suggest that OX-LDL and hs-CRP may be elevated in retinal vascular disease. Further investigations are required to determine the significance of these findings.
Authors and Affiliations
Zubair Idrees, Ian Dooley, Brian Power, Aaron Yeung, Marie Hickey Dwyer
Keywords
Related Articles
- EP ID EP342664
- DOI 10.9734/JAMPS/2014/11341
- Views 89
- Downloads 0
Development of Combined Genetic and Imaging Approaches for Differentiation of Cutaneous Malignant Melanoma and Benign Melanocytic Nevi
The morbidity and mortality rate is reduced by premature and exact diagnosis of melanoma, which is the deadliest type of skin cancer. Timely identification of melanoma needs extremely complex and subjective test and labo...
Iatrogenic Baclofen Neurotoxicity in End Stage Renal Disease: A Case Report and Review of Literature
Baclofen is a centrally acting antispasmodic agent that is commonly prescribed to patients suffering from spinal cord problems. Nearly 85% of baclofen is excreted by the kidneys whereas the remaining 15% is metabolized b...
Pain Assessment and Treatment in Pediatric Patients
Although there are a considerable number of pain assessment scales, only some of them can be used for practical intentions. The Faces Pain Scale is used for children 4 to 6-7 years old, while the Visual Analog Scale (VAS...
In vivo Evaluation of Analgesic Activities of Phyllanthus niruri Leaf Methanol Extract in Experimental Animal Models
Introduction: Phyllanthus niruri is a highly valued plant, commonly distributed in many countries of the tropics and subtropics. It has a wide range of uses as traditional medicine in many countries. However, this study...
Evaluation of Efficacy of Co-artemisinin in the Treatment of Plasmodium falciparum Malaria in Gombe State, Nigeria
Aim: To evaluate the potency and efficacy of co-artemisinin brands used in the treatment of uncomplicated Plasmodium falciparum malaria in Gombe State North-Eastern Nigeria. Materials and Methods: A total of 185 patient...