Levels of Serum Interleukin-6, Tumor Necrosis Factor-α, and Interferon-γin Patients with Tuberculous Spondylitis After AntiTuberculosis Drugs Therapy and Its Relationship to Clinical Changes
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Background: This study aims to monitor changes in IFN-γ, TNF-α and IL-6 serum levels in patients with tuberculous spondylitis during oral antituberculosis administration. Methods: With a observational prospective cohort study involving 27 patients with tuberculosis spondylitis treated at Saiful Anwar Hospital, Malang in January-December 2017, serum IFN-γ, TNF-α and IL-6 levels were measured by enzyme-linked immunosorbant assay (ELISA ) at the time prior to oral antituberculous therapy, and after 2 months of therapy. Assessed correlation relationship of cytokine levels change compared with clinical change after 2 months of anti tuberculosis drug therapy. The degree of pain was measured by VAS scores and neurologic deficits measured by Frankel score. Result: The mean TNF-α levels increased after 2 months of OAT therapy. Pearson correlation test showed insignificant results with negative correlation relationship between improvement of degree of pain with elevated levels of TNF-α (r=-0.106; p=0.598). Pearson correlation test showed insignificant results with a positive correlation relationship between neurological deficit improvement with elevated levels of TNF-α TNF-α (r=- 0.291; p=0.140). The mean IFN-γ and IL-6 levels decreased after 2 months of OAT therapy. Pearson correlation test showed significant result with positive correlation correlation between improvement of degree of pain with decrease level of IFN-γ (r=0.561; p = 0.002) and IL-6 (r=0.591; p=0.001). The Pearson correlation test showed significant results with a positive correlation relationship between neurologic deficit improvement IFN-γ (r=0.570; p=0.002) dan IL-6 (r=0.080; p=0.690). Conclusion: TNF-α levels tend to increase during therapy, but are not significant. IFN-γ and IL-6 levels decreased significantly during oral antituberculous therapy and may be considered for monitoring the success of therapy.
Authors and Affiliations
Bhrahmantya . , Tjuk Risantoso
Keywords
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- EP ID EP557569
- DOI 10.9790/0853-1803134752.
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