LIGATIONAL AND SPECTROSCOPIC ON SOME SULFAMETHOXAZOLE METAL COMPLEXES AS ANTIMICROBIAL AGENTS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Metal complexes have been applied as medicinal agents in the treatment of differenthuman infections and diseases. So, the aim of this study is focused on studying theligational, spectroscopic and evaluating antimicrobial investigations of sulfamethoxazole (SMX)drug complexes formulas with Mn (II), Cu (II), Ni (II), Zn (II), Y(III), La(III), Nd(III) and Gd(III) metal ions. These complexes with sulfamethoxazole ligand as to evaluate thebiological activity were synthesized and characterized by elemental analysis,molar conductance, magnetic susceptibility, UV-vis, IR and1H-NMR spectroscopy. The IR spectral data suggested that the coordination sites of SMX are the sulfonyloxygen and SO2-NH sulfonamide nitrogen as a bidentateligand ,from the microanalytical data, the stoichiometry of thecomplexes 1:2 (metal: ligand) was found, and the morphological nano structures of SMX complexes were checked using X-raypowder diffraction (XRD) and scanning electron microscope (SEM). The metal complexes werescreened for antibacterial activity against Gram-ve(Escherichia coli)(ATCC 8739) andGram+ve(Staphylococcus aureus)(ATCC 8739) and antifungal (Aspergillusflavus(ATCC 9643)and Aspergillusfumigatus(ATCC 1022)). These complexes considered in this research showed as a satisfactory antimicrobial activity.
Authors and Affiliations
Dr. Maher Ali Al-Maqtari
Keywords
Related Articles
- EP ID EP630417
- DOI -
- Views 164
- Downloads 0
DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE LOSARTAN POTASSIUM FORMULATION USING DIFFERENT POLYMERS
The present study was undertaken to develop and evaluate controlled release formulations of Losartan potassium by using different polymers in various drug to polymer ratios [1:1, 1:2 &1:3]. Polymers used were Eudragit RS...
UNEXPOSED UNDERGARMENTS TO SUN A MAJOR CULPRIT IN VAGINAL INFECTIONS
Objective: To determine the association between vaginal infections & non-exposure of undergarments to sun & unhygienic behaviours. Design: A cross-sectional study. Place and duration of study: Rehman Medical Institute (R...
BIOSYNTHESIS AND CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR BIOMEDICAL APPLICATIONS
Bile acids are amphiphilic molecules consisting of a hydrophobic and a rigid steroid nucleus, which they are attached a hydrophilic hydroxyl groups and a flexible acidic aliphatic side chain. The steroidal core of bile a...
ANTI-ATHEROSCLEROTIC EFFECT OF URSOLIC ACID
Vascular smooth muscle cell (VSMC) proliferation is a key event in the development of hypertension, in stent restenosis and other cardiac disorders. Drug-eluting coronary stents may delay vascular healing and increase la...
EVALUATION OF SELF MEDICATION TRENDS AMONG PHARMACY AND MEDICAL STUDENTS
Self medication is common practice worldwide and it leads to irrational use of drugs among society. This cross-sectional study was conducted to evaluate the practice of self medication and different factors linked with t...