Limbal epithelial stem cells in regeneration of corneal epithelium – clinical and molecular aspects
Journal Title: Annales Academiae Medicae Silesiensis - Year 2018, Vol 72, Issue
Abstract
Limbal epithelial stem cells (LESC) are located at the junction between the cornea and sclera. Their function is to reconstruc-ting and replace damaged or dysfunctional cells. In this paper information on the characteristics of LESC, describes the methods of their identification using surface molecular markers and also morphological characteristics are included. The methods of LESC cultivation in vitro as a potential source of stem cells for therapy are also presented. The issues of corneal disorders due to limbal stem cell deficiency (LSCD) caused by various factors were described and discussed as well as the treatment methods currently applied in medicine. The standard treatment of LSCD is based on pharmacotherapy and autologous transplantation of the limbus which is rich in stem cells. However, in the case of total stem cell deficiency (TLSCD) allogenic transplantation is necessary.
Authors and Affiliations
Bartosz Sikora, Aleksandra Skubis, Lech Sedlak, Małgorzata Kimsa-Furdzik, Marek Kostrzewski, Urszula Mazurek, Roman Aleksiewicz
Keywords
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- EP ID EP363968
- DOI 10.18794/aams/76254
- Views 88
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