Lime Juice Induces Ovarian Follicle Degeneration and Reduces Serum Gonadotrophin Level in Rats Model
Journal Title: International STD Research & Reviews - Year 2015, Vol 3, Issue 2
Abstract
Background: Lime juice possesses antimicrobial and anti-proliferative property and caused reduced sperm motility in animals. This study aimed at investigating the anti-proliferative effect of lime juice on the ovarian cortex of adult Wistar rats. Methods: Twenty (20) adult Female Wistar rats weighing between 160 - 190 g were divided into 4 groups (n= 5). Group 1, 2 and 3 received 1 ml/kg, 1.5 ml/kg and 2.23 ml/kg body weight of undiluted lime juice respectively; Group 4 received 0.5 ml of distilled water for period of ten (10) days. Administration was done by gavages oro-gastrically daily using metal oral canula. Animals were sacrificed by cervical dislocation 24 hours after the last administration of lime juice; ovary was dissected out following abdominal incision, fixed in 10% formo-saline for histological observation using H/E stains and blood sample was collected for hormonal (reproductive hormones) assay. Results: Plasma concentration of FSH and LH significantly (p < 0.05) lowered in the lime –treated rats compared with control rats, histological observation revealed degeneration in the follicular cells, stroma hyperplasia and immature follicles in the animals treated with the undiluted lime juice compared with the control group; that revealed follicular cells at different stages of development. Conclusion: Low plasma concentration of FSH and LH observed with consequent degeneration of follicular cells expressed in the ovarian cortex demonstrate anti fertility potential of lime juice.
Authors and Affiliations
B. J. Dare, O. Beremako, M. O. Shafe, S. C. Ifeonu
Keywords
Related Articles
- EP ID EP242820
- DOI 10.9734/ISRR/2015/8709
- Views 110
- Downloads 0
Vulnerability and Gonorrhea: A Qualitative Study of Black Women in South Africa
Background: Gonorrhea is becoming a health concern globally due to its susceptibility to resistance of antibiotics, and this is a concern particularly for Black women in South Africa. Vulnerability among Black women lead...
Prevalence of Diabetes Mellitus, Hypertension and Lipodystrophy in HAART Receiving HIV Patients in Southern Ethiopia
Aims: In Ethiopia, AIDS has become the leading cause of mortality in the 15-49 years age group, accounting for an estimated 43% of all young adult deaths. Though the introduction of highly active antiretroviral therapy (...
Sexually Transmitted Diseases Associated with Women Who Have Sex with Women
Aims: The aim of this work is to present the findings of various studies relevant to the incidence of sexually transmitted disease (STD) among women who have sex with women (WSW). This being an important issue when consi...
Correlates of Vulvovaginal Candidiasis among Attendees of a Special Treatment Clinic in Nigeria
Background: Vulvovaginal candidiasis (VVC) is very common with significant morbidity and health expenditure. Many cases are associated with concurrent infections with other sexually transmitted infections and several fac...
Viral Skin Infections in Adult Patients with HIV/AIDS in a Tropical Rural Practice in Nigeria
Background: The skin, like all organs in the body is affected by several diseases in patients with HIV/AIDS. This is particularly so with viral skin disorders where impaired cellular immunity seems to be a common pathway...