Limitations of serum creatinine as a marker of renal function
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 5
Abstract
Serum creatinine is widely used in the assessment of renal function to detect and prognosis of conditions with impaired renal function. Serum creatinine is a convenient test, but it has several limitations to interpret renal function. Glomerular filtration rate (GFR) estimation uses serum creatinine levels along with other variables, but still it can be erroneous due to many confounding variables. Extensive efforts by scientific community improved specificity of the creatinine assays and standardized it across different laboratories. Sensitivity of serum creatinine in severe renal impairment is better in relation to poor sensitivity in detection of early damage. Diseases of the kidney will increase tubular secretion and extra-renal elimination of creatinine. Several drugs block, tubular secretion of creatinine. Changes in muscle mass and protein metabolism significantly affect serum creatinine levels. A combination of serum creatinine and serum cystatin C was found to be less erroneous as the confounding factors for both shall not be the same. Limitations of serum creatinine levels should be considered while making relevant clinical decisions in a patient with renal impairment. Keywords:Creatinine, Renal function, Glomerular filtration rate, Muscle mass.
Authors and Affiliations
Dixon Thomas, AbdelgadirElaminEltom Elamin, Ahmed Luay Osman Hashim
Keywords
Related Articles
- EP ID EP378071
- DOI -
- Views 81
- Downloads 0
A facile method of Synthesizing Ayurvedic medicine: Lauha bhasma (iron oxide nanoparticles) & its Characterization
Iron oxide nano particles can be synthesized by various physical and chemical methods which are toxic and harmful for the environment. Ayurveda is a holistic and divine science; a modern method of synthesizing ayurvedic...
Isolation, characterization and antibacterial evaluation of Zymosterol from the Root of Pachystela Brevipes (Sapotaceae)
The root of Pachystelabrevipes, which has some medicinal applications was investigated. The results of the phytochemical analysis showed the presence of carbohydrates, cardiac glycosides, saponins, steroids/ triterpenes,...
Hepatoprotective activity of tagetes erecta Linn. in ethanol induced hepatotoxicity in rats
The plant Tagetes erecta Linn., locally known as Genda Phul (Marigold) belongs to the family Asteraceae (Compositaeis). Current study focus on hepatoprotective activity of the roots in ethanol extract by ethanol induced...
The Placebo-An Ameliorate Medicinal Power
Placebo is defined as any medication or procedure that produces an effect in patients resulting from its implicit or explicit intent and not from its specific physical or chemical properties. Positive placebo effects may...
Synthesis, Characterization and Pharmacological Evaluation of Novel Mannich bases of Thienopyrimidine Derivatives
Thienopyrimidines has received considerable attention as they are endowed with variety of biological activities and have wide range of therapeutic properties. Thienopyrimidines, the structural analogues of biogenic purin...