Linking Induction and Transrepression of PPARβ/δ with Cellular Function
Journal Title: Annual Research & Review in Biology - Year 2015, Vol 6, Issue 4
Abstract
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear hormone receptor superfamily. PPARβ/δ is ubiquitously expressed and has a central role in homeostasis, and has been suggested as a therapeutic target for a number of metabolic and cardiovascular disorders. This important nuclear receptor controls transcription under different modes of molecular activity which directly control the cellular function and fate of tissues. This complex activity of induction and transrepression of gene expression (with and without exogenous ligands) is poorly understood and yet understanding this molecular control through novel drug development would led to control over a key molecular switch in all cells. This review outlines the main molecular mechanisms of PPARβ/δ, and links the modes of activity to the signalling pathways in inflammation, proliferation and senescence, with the goal to understand how this will translate into novel drug design to control the PPARβ/δ molecular switch.
Authors and Affiliations
Noelia Perez-Diaz, Louise Mackenzie
Keywords
Related Articles
- EP ID EP353611
- DOI 10.9734/ARRB/2015/15064
- Views 91
- Downloads 0
Climatic Variables and Disease Incidence in Ghana: A Study of Cerebrum Spinal Meningitis (CSM)
Aim: The study was undertaken to evaluate the effects of climatic factors on the outbreak of Cerebrospinal Meningitis (CSM) in the Obuasi Municipality of Ghana. Significance: The project provides a validated climatic pat...
Molecular Phylogeny of Yeasts from Palm Wine and Enological Potentials of the Drink
Palm wine is consumed around the world and known by various names. Unlike many good quality traditional fermented food and drink in developing countries that have only been marketed in their local communities, palm wine...
Animal Welfare in Ecotourism
The negative welfare experienced by some animals within the tourism trade has been well publicised across various mediums, from modern scientific literature and industry audits to public outcry on social media. However,...
Screening Drought Tolerant Rapeseed Cultivars Using Yield and Physiological Indices
Rapeseed (Brassica napus) is an important source of edible oil worldwide. Rapeseed production is adversely affected by water deficit stress in drought prone areas. This study aimed to evaluate drought tolerance in sevent...
Conserving the Hidden Nature: An Overview on Conservation Efforts in United Arab Emirates (UAE)
The aim of the study is to document the threats faced by reptiles with other species in UAE and the conservation efforts done by Barari Forest Management (BFM). The study was conducted by reviewing the factors affecting...