Lipid based systems for ocular drug delivery: Effect of surface modification
Journal Title: Scholars Bulletin - Year 2017, Vol 3, Issue 8
Abstract
Abstract:Significant challenges forpharmaceutical scientists still exist despitenumerous technological advancements in the field, and the efficientoculardrug deliveryremainselusive. Exclusive and exquisite barriercharacteristics, unique physiology make the ocular milieu imperviousto xenobiotics. Precorneal residence, mucoadhesion and transmembrane permeation needs to be improved using topical non-invasive strategies across ocular surface show promise for the intraocular delivery. Viable advantages such as higher drugloading,tailored drugrelease, bio-compatibility and mucoadhesive properties can improve deliveryof lipophilic drug using colloidal nanoparticulateframeworks. Lipid based systems comprise solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Nanoparticles are better internalized in ocular epithelial tissues by endocytosis/transcytosis mechanisms and diffuse rapidly owing to their nano size. Penetration and retention characteristics of ocular small molecule therapeutics can be dramatically improved by the surface functionalization of lipid nanoparticles. This review summarizes scientific results such as articles and patents that involve the potential application of lipid nanoparticles as platform for the ocular drug delivery. Keywords: Ocular delivery, lipid based systems, surface functionalization, nanoparticles, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), transcorneal permeability
Authors and Affiliations
Thirupathi G, Ramesh B
Keywords
Related Articles
- EP ID EP382579
- DOI -
- Views 150
- Downloads 0
Correlating Students’ Participation in Music and their Academic Performance in Public Secondary Schools in Kenya
Abstract:Co-curricular activities, including literary competitions, recreational activities, cultural activities and sports clubs, provide an opportunity to learn and socialize outside the classroom. In Kenya, many resou...
Aspects of Pragmabehavioral Errors in the Acquisition of a Second Language: A case study of Kimeru L1 Learners of L2 English
Abstract:This paper highlights the pragmabehavioral errors in English used by Kimeru L1 secondary school students. The study proceeded on the premise that pragmatic competence of Kimeru L1 learners of L2 English was prev...
Relationship between Environmental Knowledge and Self Efficacy with Responsibility Environment Behavior
Abstract:The study is aimed at determining the relationship between environment knowledge and self-efficacy with responsibility environment behavior in the city of Gorontalo. The method usedin this research is a surveywi...
Parametric Analysis of Vertical Deflections of Bridges under Moving Loads
Abstract:In order to develop the sustainability of bridge engineering design in many design offices of underdeveloped countries, this work outlines design guidelines by examining the behavior of bridges vertical displace...
The Influence of Flexible Work Practices On Employee Performance in Public Sector in the Ministry of Interior and Coordination of National Government, Embu County
Abstract: The study was carried out to investigate the influence of flexible work practices on employee performance in Public sector in the Ministry of Interior and Coordination of National Government, Embu County. Resea...