Lipid Lowering potential of Andrographis paniculata (Nees)
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 2
Abstract
Aim: Atherosclerosis and associated complications is now the major cause of myocardial morbidity and mortality worldwide. Therefore we have selected the Andrographis paniculata for the development of lipid lowering drug. Material and Methods: The lipid lowering activity of mixture of andrographaloides isolated from the leaves of the Andrographis paniculata has been studied in Triton and cholesterol fed hyperlipidemic rats (in vivo). Results: Serum lipids were found to be lowered by andrographaloides (at 50 mg/kg.) in Triton WR-1339 induced hyperlipidemia in experimental animals. Chronic feeding of this mixture of andrographolides (at 25 mg/kg) in animals, simultaneously fed with high fat diet (HFD) for 30 days caused lowering in the lipid and apoprotein levels of very low density (VLDL) and low density lipoproteins (LDL) It has also increased high density lipoprotein (HDL). Andrographaloides activated lipolytic enzymes in plasma and liver lipids. The hypolipidemic activity of the andrographaloides mixture is mediated through increased faecal bile acid excretion and enhanced plasma lecithin-cholesterol acyl transferase activity. Conclusion: Mixture of Andrographolides was found to lower the lipids in experimental animals.
Authors and Affiliations
Vijai Lakshmi, Shishir Srivastav, Ashok Kumar Khanna, Abbas Ali Mahdi, Santosh Kumar Agarwal
Keywords
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