LIPID PEROXIDATION, ANTIOXIDANT PROFILE AND SOME BIOCHEMICAL PARAMETERS IN RAT APPLIED AMINOGLYCOZIDE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 1
Abstract
Amikacin were used for the treatment of infections caused by Gram (-) bacteria, have serious nephrotoxic and ototoxic side-effects. Effects of the amikacin administrated at therapeutic doses on blood lipid peroxidation, antioxidant profile and some biochemical parameters were observed in this study. A total of 40 female Wistar albino rats were used. Amikacin (15mg/kg/day i.p) was administered to the rats in the study group and physiological saline was administered to the rats in the control group for 14 days. Within these samples, the malondialdehyde (MDA), the glutathione (GSH), the vitamin A, E, C, ceruloplasmin, albumin, globulin, total protein, alkaline phosphatase (ALP), glucose, total bilirubin and blood urea nitrogen (BUN) levels were measured. The GSH, glucose, albumin and BUN levels in the study group were statistically significantly decreased compared to the first blood collection and to the control group (p˂0.05), and the total bilirubin level was increased. The changes in MDA, vitamin A, E, C, ceruloplasmin, ALP, creatine and globulin levels were not significant (p˃0.05). It was observed that amikacin did not affect lipid peroxidation formation within the blood; however it changed some antioxidant levels and biochemical parameters.
Authors and Affiliations
Enver Caner
Keywords
Related Articles
- EP ID EP620548
- DOI -
- Views 128
- Downloads 0
SYNTHESIS, CHARACTERIZATION AND ANTI-HYPERGLYCEMIC EVALUATION OF NEW METFORMIN DERIVATIVES
Metformin is a cornerstone in the treatment of type 2 diabetes particularly in obese patients. Its main actions are the suppression of gluconeogenesis and the improvement of glucose uptake and insulin sensitivity. A seri...
SURGICAL MANAGEMENT OF PAGET’S DISEASE OF THE VULVA: A CASE REPORT
Extra-mammary Paget disease (EMPD) is one of the rare neoplastic conditions of the skin that accounts for less than 1% of the vulvar malignancies. The condition typically presents as a red, velvety, pruritic skin rash of...
CYTOTOXIC ACTIVITY OF THE BIOFLAVONOID MORIN AGAINST HUMAN LEUKEMIC CELLS
The present study investigated the possibility of apoptosis-inducing activity in human leukemia U-937 and THP-1 cells by the flavonoid Morin (3, 5, 7, 2 ', 4'-pentahydroxyflavone). With the flavonol treatment in cells U-...
THE QUANTITATIVE SERUM BRCA1AND SERUM ZINC AS A NOVEL BIOMARKERS WITH THE CORRELATIONS BETWEEN THEM IN THE FAMILIAL BREAST CANCER PATIENTS IN IRAQ.
Background: Breast cancer is the most common malignant tumor in women worldwide and in Iraq. Many studies show BRCA1 and zinc are the substances that expressed significantly in tissues or serum specimens from a genetical...
COMPARATIVE STUDY OF THE ANTIMICROBIAL, MINIMUM INHIBITORY CONCENTRATIONS (MIC), CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF DIFFERENT PARTS OF PHYLLANTHUS ACIDUS (L.) SKEELS (FAMILY: EUPHORBIACEAE)
The main aim of this study was to find out and compare the antimicrobial, cytotoxic, antioxidant activity along with the minimum inhibitory concentrations (MIC) of methanolic extract of different parts of Phyllanthus aci...