LIPID PROFILE ESTIMATION IN PATIENTS WITH ORAL PREMALIGNANT DISORDERS, AND ORAL CANCER- A COMPARATIVE STUDY
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 4
Abstract
Background: The changes in lipid profile have long been associated with cancer because lipids play a key role in maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in untreated oral cancer patients and also in premalignant patients and compare with the controls. Material and Methods: The study included a total of 50 Patients who fulfilled the inclusion and exclusion criteria and who were further divided into 2 groups i.e. Habit associated premalignant and oral cancer group and control group. Serum lipid profile including Total cholesterol, HDL, LDL, VLDL and Triglyceride were analysed using semi automatic chem. 7 analyser. Statistical Analysis: Values of lipid profile obtained from the patients were evaluated statistically using one way ANNOVA and (unpaired) âtâ test. Results: A significant decrease in serum total cholesterol and LDL levels were observed in cancer patients(P=0.047 and p=0.039) as well as significant increase in serum HDL levels were observed in patients with premalignant disorders(p=0.014) when compared with controls. Conclusion: The decrease in the levels of serum total cholesterol and LDL in oral cancer patients can be due to the reason that during carcinogenesis, there is greater utilization of lipids for new membrane biogenesis.
Authors and Affiliations
Ankur Bhagat, Lavina Arya, Shailaja S, Vinod VC, Sushil Dokwal, Tammana Soni
Keywords
Related Articles
- EP ID EP557827
- DOI -
- Views 112
- Downloads 0
Histopathological Analysis of Neoplastic Lesions of Thyroid Gland
Background: Among all the endocrine disorders, thyroid disorders are the most common in India. The present study was conducted to study histopathological neoplastic lesions of thyroid. Materials & Methods: The present st...
Awareness for dental implants among Population of Bhopal: A cross sectional Study
Introduction: Dental Implant is a successful treatment modality for replacing single tooth or multiple teeth. It also prevent the natural teeth contrary to fixed partial denture therapy. Comfort level is high in implant...
EFFECT OF VALPROATE AND OXCARBAZEPINE THERAPY ON ASYMMETRIC DIMETHYL ARGININE (ADMA) AND HOMOCYSTEINE LEVELS IN NEWLY DIAGNOSED EPILEPTIC CHILDREN
Aim: The aim of our study was to evaluate the effect of valproate and oxcarbazepine therapy in children newly diagnosed with epilepsy. Changes in serum asymmetric dimethyl arginine (ADMA), homocysteine, folate and B12 le...
A prospective observational study of correlation between age and the parasympathetic nervous system
Aging is associated with changes in the cardiovascular autonomic regulation both under resting and stimulated conditions. Autonomic nervous system functions are altered with aging even in healthy subjects.So present stud...
Biosmart Dentistry â A Revelation: A Review
Various biocompatible materials have been introduced and widely used in many aspects of dental treatment. The smart response of materials occurs when it senses some stimulus from surrounding environment and reacts to it...