LIPID PROFILE ESTIMATION IN PATIENTS WITH ORAL PREMALIGNANT DISORDERS, AND ORAL CANCER- A COMPARATIVE STUDY
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 4
Abstract
Background: The changes in lipid profile have long been associated with cancer because lipids play a key role in maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in untreated oral cancer patients and also in premalignant patients and compare with the controls. Material and Methods: The study included a total of 50 Patients who fulfilled the inclusion and exclusion criteria and who were further divided into 2 groups i.e. Habit associated premalignant and oral cancer group and control group. Serum lipid profile including Total cholesterol, HDL, LDL, VLDL and Triglyceride were analysed using semi automatic chem. 7 analyser. Statistical Analysis: Values of lipid profile obtained from the patients were evaluated statistically using one way ANNOVA and (unpaired) ‘t’ test. Results: A significant decrease in serum total cholesterol and LDL levels were observed in cancer patients(P=0.047 and p=0.039) as well as significant increase in serum HDL levels were observed in patients with premalignant disorders(p=0.014) when compared with controls. Conclusion: The decrease in the levels of serum total cholesterol and LDL in oral cancer patients can be due to the reason that during carcinogenesis, there is greater utilization of lipids for new membrane biogenesis.
Authors and Affiliations
Ankur Bhagat, Lavina Arya, Shailaja S, Vinod VC, Sushil Dokwal, Tammana Soni
Keywords
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