LIPID PROFILE IN ESTABLISHED DIABETIC RETINOPATHY- A CASE CONTROL STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 6
Abstract
BACKGROUND In India, diabetes is fast gaining the status of potential epidemic affecting more than 62 million individuals. Diabetic Retinopathy is the commonest microvascular complication prevailing in 18% of DM population. This study also explores diabetic maculopathy, which is the main cause of vision loss in DR. Epidemiological studies show link between hyperlipidaemia with DR. Aims and Objectives- To establish the association of hyperlipidaemia with development and graded severity of DR and diabetic maculopathy. MATERIALS AND METHODS This case control study was performed between 100 patients of age and gender matched DR as case and 100 patients of diabetes without retinopathy as control, maintaining all inclusion and exclusion criteria at KPC Medical College, Kolkata. The study group was then graded depending on its severity based on ETDRS classification and presence of CSME. Next lipid profile was estimated and compared to find statistical significance. The statistical software SPSS version 20 has been used for the analysis. RESULTS The present study showed statistically significant correlation between diabetic retinopathy and raised total cholesterol level (p<0.001). Increased cholesterol level was significantly associated with the occurrence of all grades of retinopathy. The mean value of total cholesterol in case and control were 215.4 ± 40.8 mg/dL and 173.9 ± 33.8 mg/dL respectively. The mean total cholesterol was higher in case as compared to control. The mean triglyceride level was also higher in case (165 ± 66.5 mg/dL) as compared to control (135.6 ± 46.8 mg/dL). This correlation was statistically significant (p<0.001). In the present study, mean serum cholesterol and LDL concentration was significantly higher in severe DR subjects compared to those with less severe DR. For VLDL and TG, there were no significant differences in the concentration with the severity of DR. CONCLUSION The present study found a significant association between hypercholesterolaemia and CSME (p < 0.001). Except HDL, all mean values of lipid subfractions had significant association with CSME.
Authors and Affiliations
Ankita Bhattacharya, Ipsita Mazumdar, Ashok Kumar Maity
Keywords
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- EP ID EP399020
- DOI 10.14260/jemds/2018/181
- Views 89
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