Lipid Profile in Type 2 Diabetes Mellitus with and Without Subclinical Hypothyroidism
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 6
Abstract
In clinical practice, Diabetes Mellitus is the most common endocrine disorder. The prevalence of thyroid disorders is higher in diabetic patients as compared to general population and the most common disorder being subclinical hypothyroidism. Subclinical hypothyroidism has been claimed to be a risk factor for coronary artery disease, peripheral vascular disease and various biochemical abnormalities including dyslipidemia. The present study was planned to measure serum lipids such as total cholesterol, triglycerides, low density lipoprotein- cholesterol and high density lipoprotein- cholesterol in type 2 diabetics with and without subclinical hypothyroidism. Study includes 200 patients of type 2 diabetics with subclinical hypothyroidism and 200 type 2 diabetics without subclinical hypothyroidism. The data were evaluated statistically. We found significantly increase in total cholesterol, triglycerides and low density lipoprotein- cholesterol (p<0.001) and significantly decreased high density lipoprotein- cholesterol (p<0.001) in type 2 diabetes mellitus with subclinical hypothyroidism before therapy as compared to type 2 diabetes mellitus without subclinical hypothyroidism. After L-thyroxine therapy we observed highly significant reduction in total cholesterol, triglycerides and low density lipoprotein- cholesterol (p<0.001) and significantly increase in high density lipoproteincholesterol (p<0.001) in type 2 diabetes mellitus with subclinical hypothyroidism as compared to before therapy. Subclinical hypothyroidism is associated with atherogenic serum lipid profile pattern. Such pattern may increase the risk of atherosclerosis and CVD. L-thyroxine is of utmost importance to reduce or prevent the risk of development of atherosclerosis and CVD in type 2 DM with SCH patients.
Authors and Affiliations
Dr Karan Ningappa Pujari
Keywords
Related Articles
- EP ID EP213678
- DOI -
- Views 84
- Downloads 0
Acute Motor and Sensory Axonal Neuropathy: A Case Report
One of the subtypes of Guillain – Barre syndrome is Acute motor and sensory axonal neuropathy (AMSAN) which is characterized by acute onset of distal weakness, loss of deep tendon reflexes, and sensory symptoms. A 65-yr-...
Hydatid Cyst in Lung- A Rare Case Report
Hydatid cyst is the cystic space occupying lesion caused by echinococcus .Cystic echinococcosis is a zoonosis caused by larval stage of E. granulosus .Other less common species are vogeli, oligarthrus, multilocularis. In...
The Effect of Mouth washing with Moringa Olivera to acidity saliva level of Diabetes Mellitus Patients
Introduction: Salivary pH or acidity level changes have detrimental effects on the teeth and oral mucosa which will lead to complications of the periodontal disease. Water decoction of the leaves of Moringa Olivera conta...
Dentist Population Ratio of Bangalore City: Adequate or Inadequate-A Descriptive Study
Background: World Health Organization has raised the alarm that oral disease is one of the major public health problems. Current scenario indicates that the existing 180000 dentists are not sufficient to meet the oral he...
Clinical Profile of Optic Neuritis in Kashmiri Population
Abstract