Abstract

Objective: To evaluate the usefulness of lipid ratios in predicting coronary heart disease risk in normolipidaemic myocardial infarct (MI) patients and compare the findings with healthy controls. Methods: Lipid profile was determined in 1 021 normolipidaemic myocardial infarct patients and was compared with 1 021 age/sex-matched controls. Total cholesterol (TC), triglycerides (TG) and HDL-cholesterol (HDL-C) were analyzed enzymatically using kits obtained from Randox Laboratories Limited, Crumlin, UK. Plasma LDL-cholesterol (LDL-C) was determined from the values of TC and HDL-C using the friedwald ’s formula. The values were expressed as mean暲SD and data from patients and controls were compared using students' t-test. Results: TC, TC/HDL-C ratio, TG, LDL-C, LDL-C/HDL-C ratio were higher in MI patients (P<0.001). HDL-C concentration was significantly lower in MI patients than controls (P<0.001). Higher ratio of TC/HDL-C, TG/HDL-C and LDL-C/HDL-C was observed in acute myocardial infarct patients as compared with controls. Conclusions: Establishment of lipid ratio from routine lipid profile assay could be very useful in predicting the future risk of acute mocardial infarction.

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