Lipofundin 20% induces hepatic lipid peroxidation in New Zealand white rabbits
Journal Title: Revista MVZ Cordoba - Year 2012, Vol 17, Issue 3
Abstract
Objective. The aim of the present work was to evaluate the effects of Lipofundin 20% on lipid peroxidation markers in the liver of New Zealand white rabbits. Materials and methods. The animals were treated with an intravenous injection (2 ml/kg) of the lipid emulsion during 8 days through the marginal ear vein. At the end of the experiment some lipid peroxidation parameters and lipid profile were tested through spectrophotography. Results. Lipofundin was found to induce a significant (p<0.05) increase of malondialdehyde, total hydroperoxides, and peroxidation potential. Also, high levels of total cholesterol, triglycerides, LDL - cholesterol and HDL-cholesterol were observed in treated animals compared with the control group (p<0.05). Conclusions. Data proved that Lipofundin induces hepatic lipid peroxidation in rabbits, mainly through a mechanism which involves an induction of hyperlipidemia.
Authors and Affiliations
Livan Delgado R, M. Sc *| Center of Studies for Research and Biological Evaluations, Pharmacy and Food Sciences College, University of Havana, Havana 13600, Cuba.Correspondence: ldelgado@ifal.uh.cu, Ángela Fraga P, M. Sc| Center of Studies for Research and Biological Evaluations, Pharmacy and Food Sciences College, University of Havana, Havana 13600, Cuba., María Bécquer V, M. Sc| Center of Studies for Research and Biological Evaluations, Pharmacy and Food Sciences College, University of Havana, Havana 13600, Cuba., Ana Vázquez L, Ph. D| Center of Molecular Immunology, Havana, Cuba.
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