Lipoprotein Lipase Expression, Serum Triacylglycerol and Tissue Lipid Deposition in Rats Fed on Switching Type of Diet and Treated with Glycyrrhizic Acid
Journal Title: European Journal of Medicinal Plants - Year 2014, Vol 4, Issue 2
Abstract
Aims: To determine the anti-hyperglycaemic and anti-hyperlipidaemic effects of glycyrrhizic acid (GA), the root extract of Glycyrrhiza glabra in rats with switching type of diet i.e. between normal diet (ND) and high-fat diet (HFD). Study Design: In vivo study. Place and Duration of Study: School of Science, Monash University Sunway Campus between January 2010 and October 2010. Methodology: Sixteen Sparague-Dawley rats were divided into two groups having eight animals each i.e. group A- ND+GA→ HFD+GA; group B- ND+GA→HFD+no GA. Rats were fed with the corresponding diet and GA (100 mg/kg) for 28 days. The blood glucose, insulin and triacylglycerol levels, lipoprotein lipase expression in the liver, kidney, heart, abdominal muscle (AM), quadriceps femoris (QF), subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) and tissue lipid deposition were measured. Results: No significant difference in blood glucose levels between groups. GA significantly lowered (P=.05) triacylglycerol in rats fed on a ND with GA and later switched to a HFD without GA (group B) compared to rats fed on a ND with GA and later switched to a HFD with continuous GA supplementation (group A). For LPL expression, group B had significant lower (P=.05) LPL expression in the liver, AM, kidney and heart than group A. Group A had significantly smaller (P=.05) size of VAT than group B. Conclusion: These findings may indicate the role of GA in lowering blood glucose and triacylglycerol in subjects who had a switch from a ND with GA to a HFD without GA but not in those who had a switch from a ND with GA to a HFD with continuous GA supplementation.
Authors and Affiliations
Hui Ping Yaw, So Ha Ton, Shing Wei Ng, Khalid Abdul Kadir
Keywords
Related Articles
- EP ID EP350018
- DOI 10.9734/EJMP/2014/6700
- Views 129
- Downloads 0
An Overview of Ethiopian Traditional Medicinal Plants Used for Cancer Treatment
Traditional medicine plays a significant role in the healthcare of the majority of the people in developing countries, including Ethiopia, and medicinal plants provide valuable contribution to this practice. Emerging evi...
GC-MS Analysis of Phytocomponents and Antifungal Activities of Zanthoxylum acanthopodium DC. Collected from Manipur, India
Aims: The aim of this study was to evaluate the antifungal activity and phytochemical analysis of Zanthoxylum acanthopodium to validate the folklore use of this plant. Study Design: The present study was designed to eval...
Glial Fibrillary Acidic Protein Expression and Histopathology of Rat’s Cerebrum Following Consumption of Ethanolic Stem Extract and Juice of Costus afer
Aims: Costus afer (C. afer) is a medicinal plant commonly used as a herbal remedy for diabetes and hypertension in our country, Nigeria The aim of this study was to evaluate the effect of crude ethanolic stem extract/ju...
Study of Cytotoxic, Thrombolytic and Anthelmintic Activity of Extract of Neolamarckia cadamba (Roxb.) Leave
Aim of the Study: The study was aimed to evaluate the cytotoxic, thrombolytic and anthelmintic activity of methanolic extract of the stem of Neolamarckia cadamba (Roxb.). Place and Duration of Study: The research was ca...
Investigation of the Different Ethnopharmacological Activity of Fractional Root Extracts of Mussaenda roxburghii in in vitro Model
Purpose: With this study, we wanted to reveal that the root extract of M. roxburghii has thrombolytic activity or not and targeted to estimate its toxicity, potentiality to inhibit inflammation by the inhibition of prote...