Lipoprotein(a) : always relevant for Indians
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 7
Abstract
Lipoprotein(a) [Lp(a)] comprises of an LDL-like particle consisting of apoB which is covalently bound by a disulfide bond to apolipoprotein(a) (apo[a]). Role of Lp(a) in promoting cardiovascular disease (CVD) is well-proven. Apo(a) predisposes to atherosclerosis through its three prong actions : proinflammatory, proatherogenc and prothrombotic. The “residual risk” following adequate lowering of LDL with statins is predominantly attributable to elevated Lp(a). This particularly explains the high prevalence of atherosclerotic CVD amongst Asian Indians because as many as 40% of Indian population has elevated Lp(a). Niacin and PCSK9 inhibitors are only agents with any appreciable effect on Lp(a) lowering. The newest emerging therapy in lowering Lp(a) is a group of agents called Antisense Oligonucleotides (ASO). It remains to be seen whether lowering genetically elevated Lp(a) can reduce CVD risk.
Authors and Affiliations
Ankit Roy, Arunangshu Ganguly, Soumitra Kumar
Prevalence of urinary tract infection among pregnant women in a tertiary care hospital in West Bengal
Urinary tract infection is one of the most commonly diagnosed infections in pregnancy. Common causative organisms are Gram Negative Bacilli like Escherichia coli, Klebsiella sp. or Gram-positive bacteria like Enterococcu...
Maternal and perinatal outcome in post renal transplant patients on immunosuppressive therapy : a report of five cases
Infertility is common in patients with end stage renal disease because women do not ovulate and are unable to conceive1,2. But as renal function improves following kidney transplantation (KT), normal ovulatory cycles and...
Association of turner syndrome with hypothyroidism
To create awareness about association of turner syndrome with hypothyroidism. TS affects 1/2,500 female births and is due to the absence/structurally abnormal sex chromosome and characterized by short stature and oestrog...
Rhabdomyosarcoma : a rare case of rhabdomyosarcoma of alveolar type of hand in a 18 year old male
Rhabdomyosarcoma(RMS) is a malignant tumor arising from skeletal tissue. It is the most common sarcoma of childhood comprising of 3-4% of childhood malignancies with 2/3rd of cases being reported in children below age of...
Evaluation of antihypertensive efficacy of intravenous labetalol versus oral nifedipine in preeclamptic hypertensive emergency : a randomised controlled trial.
To compare oral nifedipine with intravenous labetalol in their rapidity to control preeclamptic hypertensive emergencies. The primary outcome is number of doses required to achieve a target blood pressure of <150/100 mmH...