Lipoprotein(a) and SYNTAX Score Association with Severity of Coronary Artery Atherosclerosis in North India
Journal Title: Sultan Qaboos University Medical Journal - Year 2012, Vol 12, Issue 4
Abstract
Objectives: Tis cross-sectional study investigated the association of lipoprotein(a) [Lp(a)] levels as an atherosclerosis predictor and their relationship to the severity of coronary artery disease (CAD). Methods: 360 consecutive patients at Sanjay Gandhi Postgraduate Institute of Medical Sciences and King George’s Medical University hospitals, Lucknow, North India, with chest pains, CAD symptoms and on lipid-lowering therapy were enrolled between June 2009 and October 2011. Before coronary artery angiography (CAG), a fasting blood sample was assessed for lipid and Lp(a) levels. Te synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score was calculated according to the CAG results. Patients were divided into 3 groups based on CAD severity and SYNTAX scores. Results: Angiography revealed CAD in 270 patients. Lp(a) levels were higher in CAD compared to non-CAD patients (48.7 ± 23.8 mg/dl versus 18.9 ± 11.1 mg/dl [P <0.0001]). Te levels of Lp(a) were lower in single than in double and triple vessels (39.3 ± 18.4 mg/dl versus 58.0 ± 23.0 mg/dl, and 69.2 ± 24.1 mg/dl, [P <0.05]). Lp(a) levels were signifcantly higher in severe CAD with SYNTAX score >30 (88.0±24.0 mg/dl). Lp(a) levels correlated signifcantly with SYNTAX scores (r = 0.70, P <0.0001). Conclusion: In this study, Lp(a) levels were positively associated with a patient’s SYNTAX score in diseased vessels. Furthermore, an elevated Lp(a) level was a causal, independent risk factor of CAD. Lowering Lp(a) levels would reduce CAD in primary and secondary prevention settings. Tere is an urgent need to defne more precisely which patients to treat and which to target for earlier interventions.
Authors and Affiliations
Fauzia Ashfaq| Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, P. K. Goel| Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, Nagraja Moorthy| Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, Rishi Sethi| Departments of Cardiology, King George’s Medical University, Lucknow, Uttar Pradesh, India, Mohammed Idrees Khan| Departments of Community Medicine & Public Health, King George’s Medical University, Lucknow, Uttar Pradesh, India, Mohammed Zafar Idris| Departments of Community Medicine & Public Health, King George’s Medical University, Lucknow, Uttar Pradesh, India
Keywords
Related Articles
- EP ID EP14284
- DOI -
- Views 290
- Downloads 8
A Massive Tuberculosis Abscess at the Erector Spinae Muscles and Subcutaneous Tissues in a Young Man
Tuberculosis (TB) is a chronic granulomatous infection which can present in an atypical form. Isolated muscle involvement is very rare. We report a 25-year-old man who presented with a massive cystic swelling on the ri...
Large Complex Odontoma A report of a rare entity
Odontomas are hamartomatous lesions composed of mature enamel, dentin, and pulp, and may be compound or complex depending on the extent of morphodifferentiation or on their resemblance to normal teeth. Tey are the mos...
Implications of Early Pregnancy Obesity on Maternal, Fetal and Neonatal Health Retrospective cohort study from Oman
Objectives: This study aimed to determine the prevalence of early pregnancy obesity among Omani women and to review maternal antenatal complications, intrapartum and postpartum events and neonatal complications among s...
Subclinical Sickle Cell Crisis during Cardiopulmonary Bypass Timely detection and early management
A sickle cell crisis can occur during cardiopulmonary bypass for cardiac surgical procedures in patients with sickle cell hemoglobin, which could lead to hemolysis. Tere is a dearth of such reports from the Arab world....
Screening of Five Common Beta Thalassemia Mutations in the Pakistani Population A basis for prenatal diagnosis
Talassemia is one of the most common autosomal single-gene disorder worldwide. Te highest prevalence of the disease is in the “thalassemia belt†which includes the Mediterranean region, parts of the Middle East, th...