Liraglutide: Unusual Drug Reaction
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
Liraglutide effectively improves glycemic control in individuals with type 2 diabetes, when used as monotherapy or in combination with one or more selected oral anti-diabetic drugs. 58 years old Egyptian male living in Makkah presented on follow up diabetes clinic with feeling unwell and nausea. He was diabetic since almost 10 years, morbidly obese, ex- smoker, IHD on treatment and post MI with 5 stents in right coronary. He was on glargine insulin 50 units/day and aspart insulin 50 units' t.i.d pre-meals. Also on Metformin XR 2250 mg/ day as well as sitagliptin 100 mg/ day and Lipitor 80 mg/day, ASA 81 mg/ day. Inspite of these combinations above his A1C was 8.3%, which led us to add for him other medication which will help him to lose weight, adjust his A1C, lower the insulin requirements and improve his CVD risk, putting in mind his history of CAD and the 5 stents he had in the right coronary. Therefore, it was decided to start him on Liraglutide injection. Drug induced-hepatotoxicity with raised liver enzymes due to liraglutide was suspected as this was the only new agent added to patient's treatment plan. We advised him to stop liraglutide immediately and to hold metformin and statin therapy till liver enzymes and creatinine back to normal levels. Liver enzymes and creatinine were back to normal levels after stoppage of liraglutide. We report this case to raise the attention regarding the importance of having baseline pancreatic enzymes as amylase, liver enzymes and creatinine before starting patients on GLP-RA medication and on follow up visits.
Authors and Affiliations
Faisal Yehia M. Al-Malky, Alaa Kamal Bahget, Bander Khalid Damanhori, Homaid Hamad Alsahafi
Keywords
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- EP ID EP548123
- DOI 10.21276/ijmrp.2017.3.3.057
- Views 81
- Downloads 0
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