Liver Enzymes and Total Protein Levels as Index of Hepatotoxicity of Naphthalene
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Hepatotoxicity, with subsequent leakage of important liver enzymes has been postulated as one of the mechanisms of naphthalene toxicity. The objective of this study was to investigate the effect of oral administration of naphthalene dissolved in olive oil on metabolism, using male Wistar albino rats, and to compare it to the control group after 14 days of administration. The twelve rats used for the experiment were divided into 4 groups. Groups 1, 2, 3 received 49 mg, 98 mg and 147 mg/kg b.w (body weight) of naphthalene respectively whereas, group 4 (control) took only the vehicle (olive oil). Slight naphthalene hepatotoxicity was evident as the result showed that mean serum ALT, AST and ALP levels were higher in rats administered naphthalene at different concentrations compared to control although, the mean differences were however, not statistically significant (p <.05). Also, mean total protein levels were significantly higher (p<.05) in rats administered naphthalene compared to the control. It can therefore be concluded that the slight elevations in mean serum ALT, AST, ALP activities in groups 1, 2 and 3 are indicative of a possible hepatic dysfunction caused by naphthalene. Elevations in mean total serum protein level are suggestive of chronic inflammation/infection. These results may be pronounced at prolonged administration of naphthalene.
Authors and Affiliations
Chukwunonyelum Ike#, Odiba Arome#, Edeke Affiong, Anunobi Ogechukwu, Ukegbu Chimere
Keywords
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