Liver Enzymes for Assessment of Severity of Organophosphorus Poisoning
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 1
Abstract
Introduction: Organophosphorus poisoning is the most common mode of poisoning in rural population of agrarian countries. In such resource limited settings proper allocation of the resources based on the need for observation in intensive care unit and ventilator need is essential. A various methods are used to assess the severity of acute organophosphorus poisoning including poisoning scoring systems and estimation of biochemical parameters such as serum acetylcholinesterase. Aims and objectives: The aim of current study was to evaluate the use of liver enzymes in assessment of severity of acute organophosphorus poisoning. Materials and Methods: A total to 320 patients between the period of December 2011 and November 2012 were studied. After applying the inclusion and exclusion criteria, a total of 80 patients were eligible for the study. The data was collected in pretested proforma. The statistical analysis was done using SPSS 17.0 software. Results: Out of the 80 patients studied, 16.3%, 15% and 10% of patients had elevated ALT, AST and ALP respectively. The increase in level of liver enzymes had no statistically significant association with mortality or respiratory depression Discussion and Conclusion: Various studies have shown liver dysfunction in chronic organophosphorus poisoning and have also identified its role in screening for pesticide exposure in high risk individuals. But, there are no studies on its relevance in acute organophosphorus poisoning. The current study shows that estimation of liver enzymes is not useful for severity assessment in acute organophosphorus poisoning.
Authors and Affiliations
Dayanand Raddi, Anikethana G V
Keywords
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