Liver function test and its alteration in female genital and gonadal carcinoma patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Introduction: Gynecological cancer is one of the most common leading cancer in worldwide as well as India. Liver function tests are helpful to evaluate patients with hepatic dysfunction. These biomarkers may be used to identify the presence of liver disease during the follow-up period. The aim of the study was to evaluate any association between liver function parameters and pattern of liver dysfunction in metastasis of female genital and gonadal cancer patients. Materials and Methods: In this study 100 female genital and gonadal cancer patients and 100 women with benign genital and gonadal diseases who attended at Out Patient Door (OPD) of IPGME&R and SSKM Hospital, Kolkata, India during the period from June, 2016 to June, 2017 were included. Liver function test (LFT) was measured by semi auto analyzer by ERBA Chem - 5 Plus V2 by TRANSASIA using spectrophotometry principle. Statistical analysis was done by SPSS 20.0.1 software. Results and Analysis: Statistical significant association was found between ALP, albumin, globulin and ratio with disease status (Table-1). The significant difference was in ALP, albumin and globulin for the cancer patients (Table-2). As per cancer stage, t-test showed that ALT of the advance stage (stage-0, I, II) of cancer patients was significantly higher than that of early stage (stage-III, IV) (t98-2.29; p=0.024) and ALP of the advance stage of cancer patients was significantly higher than that of early stage (t98-2.33; p=0.022). Discussion and Conclusion: Estimation of ALP levels in serum was less sensitive than imaging procedure, but it may be valuable for screening and early detection for metastases in female genital and gonadal cancer patients.
Authors and Affiliations
Dr. Debarshi Jana, Dr. Himadri Nayek, Dr. Samindranath Basak, Prof. (Dr) Subash Chandra Biswas
Keywords
Related Articles
- EP ID EP377314
- DOI 10.9790/0853-1707055862.
- Views 30
- Downloads 0
Non Lupus Full House Nephropathy – A Clinical and Pathological Correlation Study
Lupus nephritis is one among the most disabling complications of systemic lupus erythematosus (SLE) as it significantly increases the mortality and morbidity and relentlessly progress to end stage renal disease if not de...
An Evaluation of The Clinical And Etiological Profile of Acute Renal Failure in Obstetric Patients: An Observational CrossSectional Study
Objective: To evaluate the clinical and etiological profile of acute renal failure (ARF) in obstetric patients in Bundelkhand region. Methods: This was observational cross-sectional study. The women with previously healt...
Efficacy of Oral Zinc Acetate in Reducing Hyperbilirubinemia in Full-Term and Near-Term High Risk Neonates
Objective: To determine the efficacy of oral zinc supplementation in reducing incidence of hyperbilirubinemia and level of serum total bilirubin (STB) during the first week of life in full-term and near-term high risk ne...
The Effect of Intravenous Magnesium Therapy on Spinalanaesthesia Produced by Bupivacaine In Pre-Eclamptic Patients
Background:Magnesium has anti-nociceptive effects and potentiates opioid analgesia following its systemic and neuraxial administration. In our study, the effect of intravenous magnesium sulphate in pre-eclamptic patients...
Lethal Weapon in the Hands That Heals-Mobile Phone in Hospitals
Introduction: Mobile phones have become one of the most indispensable accessories of professional and social life, worldwide being easily accessible, economical and user-friendly Reports from Western nations have suggest...