Liver functions in patients with obstructive sleep apnea syndrome
Journal Title: The European Research Journal - Year 2018, Vol 4, Issue 4
Abstract
Objective: Previous studies showed that obstructive sleep apnea syndrome (OSAS) was associated with liver diseases such as elevated liver enzyme levels and hepatic steatosis. The aim of this study was to assess the relationship between serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and OSAS and its severity. Methods: A total of 617 patients who underwent PSG (polysomnography) between January 2016 and May 2017 were evaluated in this study. AST, ALT, total cholesterol, triglyceride levels and body mass index were analyzed. The data were analyzed using the Student t-test, ANOVA, Chi-square test, and Pearson's correlation coefficient. Results: Five hundreds and thirty patients with OSAS and 60 healthy controls were included in the study. Of the patients in the OSAS group, 17.7% had an elevated ALT level and 7.9% had an elevated AST level. There was a statistically significant difference in ALT and AST levels between the OSAS and control groups (p < 0.001 and p < 0.001, respectively). In the OSAS group, there was a statistically significant positive relationship between serum ALT and AST levels and apnea-hypopnea index (AHI), apnea index, oxygen desaturation index. Both AST and ALT levels were statistically significantly higher in obese patients than in non-obese patients (p < 0.001 and p < 0.001, respectively). ALT level was statistically significantly higher in patients without hypertension than in patients with hypertension (p < 0.001). In OSAS patients without hypertension, there was a statistically significant relationship between serum ALT and AST levels and AHI (r = 0.223, p < 0.001 and r = 0.142, p = 0.007; respectively). Conclusion: OSAS is a risk factor for elevated liver enzyme levels. Hypoxia plays an important role on liver enzymes in OSAS patients.
Authors and Affiliations
Seda Beyhan Sağmen, Elif Torun Parmaksız, Sevda Şener Cömert, Ali Fidan, Banu Salepçi
Keywords
Related Articles
- EP ID EP409218
- DOI 10.18621/eurj.381906
- Views 105
- Downloads 0
The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity
Objectives. We aimed to evaluate the frequency of toll-like receptor 4 (TLR4) gene polymorphism and its relationship between disease activity in patients with ankylosing spondylitis (AS). Methods. Forty-one AS patients (...
Is there a difference in 25-hydroxyvitamin D levels between female university students with and without joint hypermobility?
Objectives: Individuals with joint hypermobility (JH) constitute a sensitive group with regard to musculoskeletal problems. This study aimed to investigate whether females with generalized joint hypermobility (GJH) are a...
Concurrent cases of bilateral anterior shoulder dislocation: our observations in three cases
Bilateral anterior shoulder dislocations are rarely seen and usually occur due to the same mechanism arising from traumatic injuries. In here, we discussed three cases of traumatic bilateral anterior shoulder dislocatio...
Clinical and functional outcomes of extracorporeal shock wave therapy in isolated medial epicondylitis
Objective: To evaluate the effectiveness of extracorporeal shock wave therapy (ESWT) for the patients with isolated medial epicondylitis refractory to other conservative methods. Methods: A retrospective analysis of 57...
Cardiac myxomas: an analysis of 39 patients
Objectives. Myxomas are the most common benign primary heart tumors. They have serious complications including intracardiac blood flow obstruction and embolic events. The aim of the study was to assess our experiences re...