Liver Profile in Children with Dengue Viral Infection
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Background: The degree of liver dysfunction in children with dengue infection varies from mild injury with elevation of transaminases to severe injury with jaundice and liver cell failure. This study was undertaken to study the liver profile in children with dengue infection. Methods: It is a cross sectional observational study conducted in serologically positive dengue fever in children aged between 1-12years. Hepatic function was studied in all suspected cases over a period of 1 year from December 2016 to November 2017. Results: Out of 52 cases 35 had dengue fever,14 had Dengue with warning signs, 3 had severe dengue.Liver function tests showed AST levels elevated more than 45U/L in 27(77.1%) DF, 13(92.8%) DHF, 3 (100%) DSS patients. ALT levels were elevated more than 45U/L in 21(60%) DF, 10 (71.4%) DHF, 3 (100%) DSS patients. More than 10 fold increase in levels of both AST and ALT was seen in severe dengue. Total protein levels less than 6g/dl was seen in 3 (5.7%) cases. Serum bilirubin levels were more than 1.5mg/dl in 1 case with severe dengue Conclusions: The spectrum of hepatic involvement in dengue varies from jaundice to elevation of liver enzymes. Significant rise of liver enzymes helps in recognition of severe forms of dengue infection (DHF and DSS).
Authors and Affiliations
Dr. Mrinalini Das
Keywords
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- EP ID EP381180
- DOI 10.9790/0853-1708074749.
- Views 42
- Downloads 0
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