Liver Status and Oxidative Stress Activity of Wistar Albino Rat Fed Parkia Biglobosa Seeds
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 4
Abstract
Abstract: The liver as a very important organ plays a central role in energy metabolism in the body. If the liver is impaired it could lead to serious clinical integrations. The study was designed to possibly investigate the effect of boiled Parkia biglobosa at different level of dietary incorporations on the liver and oxidative stress activity using Wistar Albino Rats. Twenty Wistar Albino Rats’ age and sex matched were randomized into four groups. The control group was fed with growers mash, the group labelled A had 5% of Parkia biglobosa incorporated in their diet, the group labelled B had 10% Parkia biglobosa incorporated in their diet while the group labelled C had 20% Parkia biglobosa incorporated in their diet. The animals were fed for a period of 28 days after which they were sacrificed and serum collected from the blood for biochemical estimation. The result from liver function tests shows that there is a significant increase (p<0.05) of ALT, AST, ALP, TB, DB, protein, in the 5%, 10% and 20% as compared to the control. Result from oxidative stress reveals that there is a high level MDA and CATALASE in the 5%, 10% and 20% (p<0.05) as compared to the control. The increase in high level of serum liver enzyme markers observed in the test rats may indicate that Parkia biglobosa exhibited some hepatotoxic effect. Keywords: Parkia Biglobosa, AST, ALT, ALP, Catalase, MDA
Authors and Affiliations
Omeh Y. Saidu, Ojukwu C. Barnabas, Ejiofor U. Emmanuel
Keywords
Related Articles
- EP ID EP375286
- DOI -
- Views 51
- Downloads 0
A Comparative Study between the Fresh Frozen Plasma and Local Steroid Infiltration in the Treatment of Plantar Fasciitis
The treatment for plantar fasciitis was local steroid infiltration since many years, but recently there is a shift towards fresh frozen plasma infiltration. Hence a comparative study was done between the two methods of t...
Effect of Chronic Exposure of Sawdust in Workers Employed in Sawmills: A Cross-Sectional Study
Abstract: Increase in industrialization as well as sophisticated life style is leading to increased indoor air pollution causing major health problems in our developing country, India. Chronic exposure to saw dust affect...
Diagnostic Evaluation of Syncope By 24 hour Holter Monitoring
The aim & objective was diagnostic evaluation by Holter Monitroing of Patient with clinical diagnosis of syncope referred to Department of Cardiology at SAIMS & PG Institute, Indore. We evaluated a total of 360 pati...
A Systematic Review of Pain
The management of pain is challenging despite it being the recent focus of extensive research. A number of clinical practice guidelines for the management of pain have been published worldwide over the past 2 decades. P...
Some Platelet parameters in patients with HCV-Associated Chronic Liver Diseases
Egypt has the highest hepatitis C virus (HCV) prevalence all over the world. Thrombocytopenia is a common finding in subjects with chronic hepatitis C. The aim of the study was to measure different platelet parameters in...