Local treatment options for management of loco-regional esophageal squamous cell carcinoma
Journal Title: Revista de Medicină Militară - Year 2019, Vol 0, Issue 2
Abstract
Aim: Surgical treatment is the main treatment method for oesophagal cancer. The prognosis is poor due to high local recurrence and distant metastasis rates. The study aims to evaluate the most effective local treatment modality oesophagal squamous cell carcinoma (SCC) according to real-life data. Method: 136 patients were studied retrospectively. All patients were middle or lower oesophagal cancer and had the SCC histology. Patients were divided into the surgical resection, definitive CRT (dCRT), and multimodal treatment groups according to the curative local treatment they received. Result: 32.4% were in the surgical, 36% were in the dCRT, and 31.6% were in the multimodal group. Median disease-free survival was 21 months (95% CI 14-27) in the surgical group, 8 months (95% CI 4-11) in the dCRT group, and 18 months (95% CI 0-39) in the multimodal group (p=0.059). The median overall survival was found to be 40 months (95% CI 0-92) in the surgical group, 19 months (95% CI 15-22) in the dCRT group, and 54 months (95% CI 11-96) in the multimodal group (p=0.012). In the multimodal group, the number of patients receiving preoperative CRT was 25, and postoperative CRT was 18. Median OS was 47 months (95% CI 0-99) in the preoperative CRT group, and 64 months (NA) in the postoperative CRT group (p=0.302). Conclusion: DFS and OS contributions of multimodal treatment in oesophagal SCC have been shown in the present study. The addition of CRT to surgery in the preoperative or postoperative period has a contribution independently of the treatment sequence.
Authors and Affiliations
Tülay Eren, Gökşen İ. İmamoğlu, Fatih Yildiz, Süheyla A. Arslan, Sultan A. Kocacan, Salih Z. Çakar, Ozan Yazici, Doğan Yazılıtaş, Nuriye Özdemir, Berna Öksüzoğlu
Keywords
Related Articles
- EP ID EP610496
- DOI -
- Views 53
- Downloads 0
The story of a journal – The 120th anniversary of the Romanian Journal of Military Medicine
-
Capabilities for identification and confirmation of bacterial biological agents
Military Medical Service is able for detection, identification and confirmation of biological agents; it is part of medical protection against CBRN weapons. We are specialized capabilities for in vitro tests, under const...
Principles of antimicrobial therapy in urosepsis: an approach from the perspective of the infectious diseases physician
Background: This topic is aimed to review the treatment approach in adult patients diagnosed with urosespsis, in order to decrease mortality and to maximize the outcome of the antibiotic stewardship efforts. Methods: We...
The role of metatarsophalangeal joint arthroscopy in hallux rigidus treatment: technique and early results
Introduction: The hallux rigidus is a term that signifies a mobility limitation of the metatarsophalangeal joint of the big toe due to osteoarthritic degeneration. Several factors are incriminated in the appearance of th...
The surgical treatment of decubitus lesions
Several methods have been exercised during the past years, thus offering the surgeon the possibility to choose when planning reconstructive surgery. Among these methods, we recall: the dislocation of a large surface of s...