Locomotor Behaviour and Anxiety in the Open Field and Light/Dark Box in CD1 Mice Treated with Aspirin, Cataflam and Ethanolic Extract of Cannabis sativa
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 6, Issue 6
Abstract
Aims: To study the effects of cataflam, aspirin and the ethanolic extract of Cannabis sativa on nociception in CD1 albino mice of both sexes. Methods: Twenty (20) albino mice were divided into four (4) groups of five (5) each. The control group (group 1) received normal saline orally. Meanwhile groups 2-4 received p.o. cataflam (1.5 mg/kg), aspirin (13.5mg/kg) and Cannabis sativa (10 mg/kg) respectively. All four (4) groups were given access to normal mice chow and water ad libitum. The Open field apparatus and the light/dark box were used to measure locomotor/exploratory behaviour and anxiety. Results: There was a significant (p=0.05) reduction in the frequencies of rearing, walling and line crossing in the Open field test and a reduction in frequency of transition, rearing and line crossing in the light/dark box. There was no significant difference in the chamber durations in the light/dark box test. Conclusion: Cataflam, Aspirin and the ethanolic extract of Cannabis sativa all have anxiogenic effect and reduced locomotor behaviour. The ethanolic extract of Cannabis sativa seems to have the greatest anxiogenic effect, followed closely by Cataflam and Aspirin.
Authors and Affiliations
C. O. Nku, G. O. Oghale, I. O. Ajiwhen
Keywords
Related Articles
- EP ID EP347095
- DOI 10.9734/BJMMR/2015/15032
- Views 50
- Downloads 0
Morning Salivary Cortisol Associates with Elevated Serum Leptin Levels in Jordanian Young Men with Olive Pollen Induced Allergic Rhinitis
Aims: Recent studies have shown independently inter-correlations between allergy, obesity, leptin hormone, and stress markers. However, these findings were unclear and contradictory. Thus the aim of the present study is...
Effects of Initial Periodontal Treatment in Moderately Compensated and Decompensated Type 2 Diabetic Patients
Objective: The objectives of this research were to evaluate the effect of periodontal therapy in moderately compensated and decompensated type 2 diabetic patients. Materials and Methods: 20 patients with type 2 diabetes...
Blind Eye Associated with Osteosarcoma
We report the case of a 10 year old girl with a late diagnosis of a high grade osteosarcoma (Stage IIb) of the right femur in a low income setting. The diagnosis could clinically have been made much earlier if the observ...
Efficacy of Dental Floss Impregnated with Commercially Available Mouthwashes on Reduction of Supragingival Biofilm: A Randomized Single Blind Study
Aim: To evaluate the efficacy of dental floss impregnated with commercially available Chlorhexidine gluconate, Cetylpyredinium Chloride and Chlorine dioxide mouthwash on reduction of Supragingival Biofilm. Materials and...
Silent Myocardial Infarction Due to Kounis Syndrome
Bee stings can cause mortal anaphylactic reactions, which are also precursors to some other mortal events. Kounis syndrome (KS), or allergic myocardial infarctions, are well known concomitant events with every type of al...