LONG TERM CONSUMPTION OF THERMOXIDISED OR PHOTOXIDISED PALM OIL DIETS IS ASSOCIATED WITH SYSTEMIC EXPRESSION OF OXIDATVE STRESS BIOMARKERS IN WISTAR RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 8
Abstract
Several researches have demonstrated that consumption of thermoxidised palm oil (TPO) or photoxidised palm oil (PPO) diets impairs tissue functions in many organ systems suggestive of a systemic toxicity. It is also known that lipid peroxidation of tissues results in tissue damage and consequent dysfunction from oxidative stress, a common pathway in many pathological conditions. But evidence on the general peroxidative status of the animals following long term ingestion of these forms of palm oil is lacking. Fifteen male wistar rats weighing 80 -122g and aged 20-23 weeks were divided into control, PPO-fed and TPO-fed groups of five rats each. Control group was fed on normal rat feed while the PPO-fed and TPO-fed groups were fed on PPO and TPO diets respectively for 13 weeks and their blood samples evaluated for serum catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA) levels as biomarkers of oxidative stress. Serum MDA concentration in TPO-fed and PPO-fed groups was significantly increased (p<0.001) compared with control. It was also significantly increased in the PPO-fed group p<0.01) compared with the TPO-fed group. Serum concentration of CAT in the TPO-fed and PPO-fed groups was significantly decreased (P<0.01 and p<0.001 respectively) compared with control. Serum GPx concentration in TPO-fed and PPO-fed groups was also significantly decreased (P<0.05 and p<0.001 respectively) compared with control. In conclusion, long term ingestion of TPO or PPO diets is associated with systemic expression of oxidative stress biomarkers in wistar rats.
Authors and Affiliations
Ekpe Okpata Aribo
Keywords
Related Articles
- EP ID EP637897
- DOI -
- Views 132
- Downloads 0
A REVIEW OF THE MULTIFACETED USEFULNESS OF CELOSIA ARGENTEA LINN
In modern medicine today, medicinal plants have been the major source of drugs, playing vital role in drug development programme of the pharmaceutical industry and providing cure for man. In rural areas of developing cou...
SEXUAL AND REPRODUCTIVE HEALTH NEEDS AND PRACTICES: A COMPARATIVE STUDY OF HIV DISCORDANT AND CONCORDANT COUPLES ACCESSING CARE AT COMPREHENSIVE HEALTH CENTERS IN A SOUTHEASTERN STATE IN NIGERIA.
Background: A comprehensive picture of the sexual and reproductive health needs and practices of HIV- discordant couples is key in improving the efficacy of interventions for them. Objective: To compare the sexual and re...
CARDIOVASCULAR RISK FACTORS AMONG ADULTS IN THE UNITED ARAB EMIRATES.
Background: Cardiovascular disease (CVD) has emerged as a major cause of morbidity and mortality. Research on CVD risk factors is necessary to reduce or overcome the risk of cardiovascular disease incidence. The knowledg...
EVALUATION OF ALPHA-AMYLASE AND ALPHA-GLUCOSIDAE INHIBITORY POTENTIAL OF SEDUM SARMENTOSUM
The purpose of present study was to investigate the effects of extracts of Sedum sarmentosum a traditional vegetative plant, on α-amylase and α-glucosidase activities in vitro. The three tissues (leaves, stems, and roots...
ASSESSMENT OF WATER, SANITATION AND HYGIENE AMONG BASIC SCHOOLS IN ELOBEID
Background: Water and sanitation improvements, in association with hygiene behavior change, can have significant effects on population and health by reducing a variety of disease conditions such as diarrhea, intestinal h...