Long term effects of various therapies on the metabolic risk factors in prostate carcinoma patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 3
Abstract
Abstract: The objective is to investigate the long term effects of androgen deprivation therapy and non-androgen deprivation therapy on various metabolic risk factors in prostate carcinoma patients. It was a hospital based prospective study consisted ofeighty eight subjects with diagnosed prostate carcinoma and twenty five aged matched healthy controls for the comparison of basic parameters at the initial level. The prostate carcinoma subjects were divided into two groups on the basis of metastatic prostate carcinoma and locally confined prostate carcinoma viz. androgen deprivation therapy (n=51) and non-androgen deprivation therapy (n=37). The subjects were examined for Adult Treatment Panel III criteria for metabolic syndrome. Anthropometric parameters were measured and biochemical parameters estimated at baseline and after 12 and 18 months of therapy. The anthropometric and biochemical parameters were significantly increased and insulin sensitivity was significantly decreased in androgen deprivation therapy group after the therapy of 18 months. However, in non-androgen deprivation group this change was non-significant.The results of the present study suggest that men with prostate carcinoma who receive androgen deprivation therapy develop insulin resistance and hyperglycemia as compared to those who received non androgen deprivation therapy. Hence, it may be stated that androgen deprivation therapy increases the metabolic burden. However, the level of high density lipoprotein also increases significantly in androgen deprivation therapy group which shows the difference with classical metabolic syndrome. Keywords:Prostate carcinoma, Androgen deprivation therapy, Insulin resistance, Cardiovascular disease
Authors and Affiliations
Priyanka Jain, Sonali Sharma, Manju Jha, Ajay Bapna
Keywords
Related Articles
- EP ID EP371386
- DOI -
- Views 80
- Downloads 0
A Comparative Study on Cardiovascular Autonomic Function Tests Indices between Young Healthy Males and Females
Several earlier tudies have reported that gender influences cardiovascular autonomic reactivity among adult. So present study was initiated and an attempt was made to bring out the association of autonomic functions with...
Study of Bacterial Profile & Complications of Asymptomatic Bacteriuria in Pregnancy
Abstract: Asymptomatic bacteriuria (ASB) is presence of bacteria in urine without causing any symptoms. As symptoms do not manifest, this entity goes undetected. But in case of pregnanacy this condition poses a serious t...
Evaluation of Cortico - Medullary Differentiation of Lithotripsy Patients using Ultrasound in Sudan
Abstract: This is an observational cross-section study conducted in Khartoum state Sudan, it aimed to evaluate the kidneys Ultrasound scans of renal stone patients who underwent lithotripsy treatment. The kidneys of 156...
Study on dyslipidemia and oxidative stress in Elderly- A clinical approach to predict cardiovascular disease risk
Abstract: Aging is characterized by systemic deterioration of biomolecules and increased incidence of oxidative stress. In addition, occurrence of dyslipidemia in elderly significantly contributes the development of card...
Study of Hospital Based Epidemiology & Clinical Types of Cases of Dermatophytosis Presenting in Outpatient Department of Skin and Venereology
In India, which is a tropical country, the cause of dermatophytoses is adversely influenced by economic factors like poverty, poor hygiene and social conditions like overcrowding. Nature of dermatophytosis may change wit...