Long Term Survival and Late Toxicities in Inoperable Carcinoma Esophagus Treated wth Concurrent Chemotherapy and Radiotherapy
Journal Title: Indian Journal of Cancer Education and Research - Year 2019, Vol 7, Issue 1
Abstract
Introduction: Results of treatment in carcinoma esophagus have not been very encouraging as it usually presents in an advanced stage. We treated these inoperable carcinoma esophagus patients with concurrent chemotherapy and radiotherapy and got early symptomatic relief and good long term survival. Material & Methods: 46 patients included in this study were treated with induction chemotherapy with methotrexate on day 1 and cisplatin on days 2 to 5 followed by radiotherapy from day 6 and further cisplatin was given on days 21, 28 and 35 concurrently with radiotherapy. Results: Symptomatic relief was seen during the second week and 69.56% patients had local control at 1 year. The 3-year and 5-year overall survival (OS) was 47.83% and 15.22% respectively, with a median survival period of 32 months. Conclusion: This regime of sequential chemotherapy followed by radiotherapy and concurrent chemotherapy has given better overall survival with acceptable toxicities.
Authors and Affiliations
Virendra Bhandari
Keywords
Related Articles
- EP ID EP630386
- DOI 10.21088/ijcer.2321.9815.7119.1
- Views 72
- Downloads 0
Hypoxia Inducible Factor-1 (HIF-1) and Cancer Progression: A Comprehensive Review
Hypoxia is characterized as a decrease oxygen levels in tissue, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. The key component of hypoxia sensing in the cell is the hypox...
Weekly Versus Three-Weekly Cisplatin in Concurrent Chemoradiotherapy for Head and Neck Squamous Cancers: A Prospective Study
Concurrent chemoradiotherapy (CT-RT) is often used as definitive treatment for patients with locally advanced head-and-neck squamous cancers (HNSCC). Concurrent cisplatin administered 3- weekly (100 mg/m2 on days 1, 22 a...
Malignant Intracerebral Nerve Sheath Tumor: A Rare Case Report
Malignant peripheral nerve sheath tumours are very uncommon and can be found associated with neurofibramatosis Type I. Their prognosis is poor and surgery remains the treatment of choice. Radiotherapy and chemotherapy ar...
Prospective Analysis of Dosimetric Parameters and Toxicity Outcomes in Cervical Cancer Patients undergoing Concurrent Chemoradiation with Bonemarrow Sparing IMRT Using Spect Correlation
Aim: Study was to evaluate feasibility and benefits of Bone Marrow Sparing IMRT over Standard IMRT. Materials and Methods: Cervical cancer patients undergoing Concurrent Chemo Radiation and brachytherapy and evaluated...
Magic Mouth Wash V/s Benzydamine Mouth Wash in Prophylaxis and Treatment of Radiation Induced Oral Mucositis in Patients with Head and Neck Cancers: A Prospective Study
Background: The incidence of mucositis is increased by adding concurrent chemotherapy as well as by altered fractionation radiation. The main aim of the study is to compare the efficiency of magic mouth wash and benzydam...