Low Alpha-Fetoprotein (AFP) Producing Hepatoblastoma - An unusual Case Report
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Hepatoblastoma is the most common malignant liver tumour in children and comprises approximately 1% of pediatric cancers. Nearly 90% of cases occur between the ages of 6 months and 5 years. The lesion has a male preponderance. The tumour has been seen in association with a variety of congenital abnormalities, wilms tumour, glycogen storage disease and famalial colonic polyposis. Case report: An one year old female was admitted with symptoms of gradual loss of appetite and weight. A mass was noted in the upper abdomen since 2 months. Patient’s serum AFP level was 7.3 IU/ml. The patient underwent wedge resection of left hepatic lobe tumour. Gross examination revealed a bosselated tissue measuring 8×6×4 cm. Microscopically, it shows presence of both fetal and embryonal epithelial cells as well as osteoid. Immunohistochemistry for Hep-par1, CK 19 were positive and AFP was only focally positive. Conclusion: Low AFP producing hepatoblastoma is a rare pediatric tumor which is found in 5-10% of patients. Very low and very high AFP levels are associated with poorer prognosis than intermediate AFP level. The survival rate of hepatoblastoma is better than hepatocellular carcinoma and largely determined by clinical stage.
Authors and Affiliations
Bidhan Ch Das, Upam Kr. Sharma
Keywords
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