Low Dose Nalbuphine in Attenuation of Hemodynamic Responses to Laryngoscopy and Intubation – A Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Various pharmacological interventions and methods have been tried to obtund the hemodynamic responses to laryngoscopy and intubation. A randomised, controlled, double blinded study was conducted in our centre on sixty adult patients scheduled for elective surgical procedures under general anaesthesia, randomised into two groups viz. Group A patients (100µg//kg nalbuphine intravenously) and Group B (150µg/kg nalbuphine intravenously), administered 5 minutes before induction. During laryngoscopy and endotracheal intubation, changes in the heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure were recorded at baseline, after the study drug, at intubation, 1, 2, 3, 4, 5 and 10 minutes. An increase in the heart rate in group A from 89.10±3.58 to 98.46±2.96 beat per minute (10%), and in group B from 86.83± 2.83 beat per minute to 96.63±3.09 per minute (11%) was observed (p>0.05). A rise in systolic blood pressure during laryngoscopy and intubation compared to the baseline value i.e. 6% from baseline (p=0.01) was observed in both the groups. However, the mean arterial pressure (MAP) dropped from 95.55±2.43 to 87.60±2.46 mmHg (8%) in group A as compared to group B from 95.33±2.40 to 84.53±2.77mm Hg (11%) during intubation (p>0.05) but was significantly decreased when compared to the baseline in both the groups (p=0.02). It was concluded that nalbuphine in the two low doses effectively reduced tachycardia, hypertension associated with laryngoscopy and intubation. It also provided good intra operative haemodynamics and adequate post-operative analgesia.
Authors and Affiliations
Dr I. Joyshankar Singh, Dr. Takhelmayum Hemjit Singh, Dr. N. Ratan Singh, Dr. Laithangbam Pradipkumar Singh, Dr. Ritchie Edmund Pasweth, Dr. Rita Raj kumari
Keywords
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- EP ID EP444219
- DOI 10.9790/0853-1801143237.
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