Low Prevalence of Plasmodium vivax - Plasmodium falciparum Mixed - Infection in Patients from Central and Eastern Part of Sudan: Implication for Case Management in Sudan
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2014, Vol 4, Issue 8
Abstract
Accurate diagnosis of malaria parasite species is crucial for rational treatment that is a key success for a malaria control and elimination programmes. The main objective of this investigation was to correct species identification and re-assessment of diagnosis method in central and eastern part of Sudan. The blood samples were collected from 71 febrile cases infected with P. vivax in Eastern and Central Sudan, diagnosed by light microscopy and also by nested-PCR assay, using 18S small sub-unit ribosomal RNA (ssrRNA) gene. The nested-PCR were detect 92.9% (66/71) and 2.8% (2/71) P. vivax and P. falciparum mono-infection, respectively. Based on microscopy method, the level of mixed - Infection was zero; however, nested-PCR assay detected 4.2% (3/71) mixed infections in collected samples. In detecting P. vivax infection, microscopy had high sensitivity (97%) and specificity (50%). In conclusion, the present data point to the need of improving microscopy diagnosis method in malaria endemic region and also suggest that although molecular techniques are not practical for diagnosis of P. vivax and P. falciparum mixed infections in any areas; these could be used to collect epidemiological facts for control and elimination of the disease in Sudan.
Authors and Affiliations
Albadawi A. Talha, Sakineh Pirahmadi, Elgaily M. Elgaily, Sedigheh Zakeri, Bakri Y. M. Nour
Keywords
Related Articles
- EP ID EP343403
- DOI 10.9734/IJTDH/2014/10916
- Views 57
- Downloads 0
Paediatric Morbidity and Mortality in a Suburban Hospital in Jos, North -Central Nigeria
Background: Even though there has been some decline in childhood mortality, figures still remain high in sub- Saharan Africa. The pattern of morbidity and mortality in health care institutions may be a reflection of the...
Clinicians’ Adherence to Implementation of Test, Treat and Track Strategy for Malaria Control among Children Under-five Years in Ho Municipality, Volta Region, Ghana
Background: The World Health Organization emphasized testing and confirming every suspected malaria case with either Rapid Diagnostic Tests (RDTs) or microscopy before treatment with anti-malarial drugs. Over 80% of case...
Nine Years of Malaria Cases in Bangladesh: A Time Series Analysis
Aims: Bangladesh, a malaria endemic country in South East Asia Region, has successfully decreased malaria over the years through the adoption of different strategies. Still, this is un-notified and no systematic malaria...
Heavy Metal Contamination of Herbal Drugs: Implication for Human Health-A Review
Interest in the use of medicinal plants in treatment of diseases in Africa has increased tremendously over the past decade. Ingestion of contaminated medicinal plants and herbal medicinal products is regarded as potentia...
Comparative Analysis of Clinical Factors Affecting Quality of Life among HIV Positive Clients in Peer Support Group in a Tertiary Hospital in Anambra State, Nigeria
Background: The new test and treat paradigm for HIV positives irrespective of CD4 count may significantly reduce HIV and related illnesses. Further inroad into the effects of social support and clinical factors on qualit...