<strong>IgG Avidity: an Important Serologic Marker for the Diagnosis of Tick-Borne Encephalitis Virus Infection</strong>

Journal Title: Polish Journal of Microbiology - Year 2016, Vol 65, Issue 1

Abstract

A total of 52 serum samples from patients with symptoms suggestive of tick-borne encephalitis virus (TBEV) infection and positive IgM and/or IgG antibodies were tested for IgG avidity. Acute/recent TBEV infection was confirmed by low/borderline avidity index (AI) in 94.8% IgM positive/IgG positive samples, while in 5.2% high AI was found indicating persisting IgM antibodies. Majority of IgM negative/IgG positive samples (78.6%) showed high AI consistent with past TBEV infection. However, in 21.3% patients without measurable IgM antibodies current/recent infection was confirmed by AI. IgG avidity represents an additional serologic marker that improves diagnosis of TBEV, especially in cases of atypical antibody response.

Authors and Affiliations

Tatjana Vilibic-Cavlek, Ljubo Barbic, Vladimir Stevanovic, Goranka Petrovic, Gordana Mlinaric-Galinovic

Keywords

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  • EP ID EP81070
  • DOI -
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How To Cite

Tatjana Vilibic-Cavlek, Ljubo Barbic, Vladimir Stevanovic, Goranka Petrovic, Gordana Mlinaric-Galinovic (2016). <strong>IgG Avidity: an Important Serologic Marker for the Diagnosis of Tick-Borne Encephalitis Virus Infection</strong>. Polish Journal of Microbiology, 65(1), 119-121. https://europub.co.uk/articles/-A-81070