LUBIPROSTONE: A NOVEL DRUG TO TREAT CONSTIPATION
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 2
Abstract
Lubiprostone, a bicyclic fatty acid, is a novel drug of new class of agents called prostones. It is approved by US FDA for the treatment of chronic constipation and constipation associated irritable bowel syndrome (IBS-C). It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit and improve symptoms of constipation. Lubiprostone is well tolerated in majority of the patients with nausea being the most common adverse effect. Lubiprostone represents a new approach of treatment in cases of resistant or intolerable cases of chronic constipation with proven efficacy and safety.
Authors and Affiliations
Kamlesh Garg*| Assistant Professor, Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi, Surinder Kumar| Medical officer, Department of Anesthesia, VMMC and Safdarjung Hospital, New Delhi, Ruchika Nanda| Assistant Professor, Department of Pharmacology, Dr HSJ Institute of Dental Sciences, Panjab University, Chandigarh, Suraj B| Junior Resident, Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi
Keywords
Related Articles
- EP ID EP1345
- DOI -
- Views 653
- Downloads 53
IMPROVEMENT OF FAST DISINTEGRATING TABLETS USING RANITIDINE HCL
The present study was designed towards the design and development of fast disintegrating tablets by direct compression technology using Ranitidine HCl as a model drug. Fast disintegrating tablet of Ranitidine HCl was for...
EVALUATION OF PKD2 GENE (G/C) POLYMORPHISM IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AMONG SOUTH INDIANS (MADURAI).
Polycystic kidney disease (PKD) is the leading causes of end-stage renal failure (ESRD) and a common indication of dialysis / renal transplantation. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal rece...
AN OVERVIEW ON MORINGA OLEIFERA: A POTENTIAL MEDICINAL HERB
Moringa Oleifera tree is known as miracle tree, as an almost every part of this tree possesses product useful for humans. It is a multipurpose tree, used in very commonly in the spice, cosmetic oil, and as a medicinal us...
FORMULATION, OPTIMIZATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF DOMPERIDONE
Fast dissolving dosage form (FDDF) is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such formulation readily dissolve or disintegrate in the saliva generally within...
DEVELOPMENT OF SUSTAINED RELEASE DOSAGE FORM OF GLICLAZIDE
The main aim of present work was to prepare solid dispersion of poorly water soluble drug Gliclazide to enhance its in-vitro dissolution rate and aqueous solubility of drug. Gliclazide is a second generation of hypoglyce...