Luteolysis and luteostasis – the tripod of life or death for Corpus luteum and its synthesi of Progesterone in mammals
Journal Title: Journal of Sustainable Veterinary & Allied Sciences - Year 2022, Vol 2, Issue 1
Abstract
Corpus luteum (CL) is a transient organ with primary function of producing progesterone, which is essentially required for establishment and sustainance of pregnancy. Luteolysis and luteostasis are two major events that determine life span of corpus luteum within the anatomical space of the ovary and physiological time frame of oestrous cycle that is designated as oestrus to oestrus in a non-conceptive cycle or oestrus to parturition in a conceptive cycle. During oestrus cycle, corpus luteum usually undergoes degradation and hence, cessation of CL synthesis of progesterone so that the animal could return back to oestrus sequel to removal of progesterone inhibition on the release of the gonadotropins that initiate folliculogenesis and ovulation. During pregnancy, corpus luteum must not regress; rather it must be sustained for continual production of progesterone which is essentially required for establishment and maintainance of pregnancy. Therefore, luteolysis must be abrogated and it is called luteostasis. Abrogation of luteolysis during pregnancy to rescue corpus luteum is initiated via different mechanisms in different mammalian species in a phenomenon called maternal recognition of pregnancy. Luteolysis during pregnancy leads to abortion while failure of luteolysis to occur in a non-conceptive cycle keeps the animal in dioestrus stage of the cycle and non-return to oestrus. Luteolysis and luteostasis are reciprocally connected and represent well-orchestrated mechanisms strictly under hormonal regulation that occur throughout mammalian reproductive life. The molecular mechanisms underlying the two opposing reproductive phenomena are further discussed in this review.
Authors and Affiliations
Jimoh, A. A, Raheem, K. A. & Raji L. O.
Keywords
Related Articles
- EP ID EP710924
- DOI 10.54328/covm.josvas.2022.065
- Views 73
- Downloads 0
Rabies immune status of vaccinated and unvaccinated dogs in Kwara State, Nigeria
Rabies is one of the deadliest zoonoses that have existed for decades, affecting wide range of hosts globally. In Nigeria, there is paucity of data on routine antibody check of antirabies vaccinated dogs as quality assur...
Validation of two human point-of-care glucometers for glucose concentration determination in rats
Glucose disorders associated with critical illness are common in veterinary medicine and availability of efficient, easy and affordable diagnostic process is vital in combating the menace. Point-of-care glucometers readi...
Fractions of Lawsonia inermis Linn leaves reversed the damage caused to major organs involved in diabetic complications by improving their histomorphological appearance in diabetic Wistar rat model
Diabetes mellitus (DM) is clinically known as diverse sets of biochemical syndromes with a basic symptom of glucose intolerance and is a major cause of morbidity and mortality worldwide. Diabetes mellitus exclusively dis...
Foot-and-mouth disease virus serotype O, East African Topotype 3 (EA-3) in a pastoral herd in Kaduna state, Nigeria Journal of Sustainable Veterinary &
A case of foot and mouth disease involving an uncommon serotype of the Foot and Mouth disease virus (FMDV) is reported in a 6-year-old Bunaji bull from a pastoralist herd in Tohu, Sabon Gari Local Government Area of Kadu...
Anatomical Demonstration of the Cognitive Ability of the Juvenile African Giant Pouched Rat (Cricetomys gambianus – Waterhouse, 1840)
Cognitive ability in animals is determined using indices such as Encephalisation Quotient (EQ), relative brain weight, glial quotient and neuronal index. In this study, the cognitive ability of the juvenile African giant...