LUTING AGENTS DIFFERENTIALLY MODULATE INFLAMMATION AND MATRIX METALLOPROTEINASES IN CONNECTIVE TISSUE
Journal Title: Revista Científica do CRO-RJ / Rio de Janeiro Dental Journal - Year 2018, Vol 3, Issue 1
Abstract
Objective: The objective of this study was to evaluate the tissue response and expression of matrix metalloproteinases (MMP) -2 and -9 to resinous and glass ionomer cements in direct contact with the subcutaneous connective tissue. Methods: RelyXTM Unicem resinous cement (RC; n=30), KetacTM Cem Easymix glass ionomer cement (GI; n=30), and polyethylene empty tubes (control; n=30) were implanted in the dorsal subcutaneous tissue of isogenic BALB/c mice, and the tissues were biopsied after 7, 21, and 63 days for histological analysis. The inflammatory cells and fibroblasts were counted, and the fibrous capsule thickness was measured. MMP -2 and MMP-9 expression levels were investigated by immunohistochemistry. Data were analyzed statistically (significance level=5%). Results: We found that RC induced a low inflammation at day 7 and 21, which was increased at day 63 (p<0.05). GI induced a more intense mononuclear inflammatory response at day 7 and 21 (p<0.05), which was reduced at day 63 to levels similar to the control (p>0.05). The fibrous capsule thickness was thin for RC, GI, and control (p>0.05).MMP-2 was detected early for GI and RC and decreased afterwards. MMP-9 presented a similar pattern for GI, whereas the MMP -9 expression was late for RC. Conclusion: Resinous cementRelyXTM Unicem induced an inflammatory response and late MMP -9 expression in the subcutaneous connective tissue that was different from that induced by KetacTM Cem Easymixglass ionomer cement.
Authors and Affiliations
Alexandra Mussolino de Queiroz, Thais Helena Andreolli do Amaral, Francisco Wanderley Garcia Paula Silva, Paulo Nelson Filho, Raquel Assed Bezerra da Silva, Patrícia Maria Gaton-Hernández, Léa Assed Bezerra da Silva
Keywords
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