Lymph Node Blood Vessels: Exit Route for Systemic Dissemination of Cancer
Journal Title: Interventions in Pediatric Dentistry Open Access Journal - Year 2018, Vol 1, Issue 1
Abstract
There are reports about the existence of meningeal lymphatic vessels in human and nonhuman primates (mormoset monkeys) and feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with graduator, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside Dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, meningeal lymphatics display a typical panel of lymphatic endothelial markers by immunochemistry. This discovery holds promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases. How does the brain rid itself of waste products? Other organs in the body achieve this via a system called the lymphatic system. A network of lymphatic vessels extends throughout the body in a pattern like that of blood vessels. Waste products from cells, plus bacteria, viruses and excess fluids drain out of the body’s tissues into lymphatic vessels, which transfer them to bloodstream. Blood vessels then carry the waste products to the kidneys, which filter them out for secretion. Lymphatic vessels are also a highway for circulation of white blood cells, which fight infections, and are therefore an important part of the immune system. Unlike other organs, the brain does not contain lymphatic vessels.
Authors and Affiliations
Robert Skopec
Keywords
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- EP ID EP576081
- DOI 10.32474/CTBM.2018.01.000104
- Views 91
- Downloads 0
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