Lymphocyte-suppressing action of simvastatin in patients with isolated hypertriglyceridemia.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 3
Abstract
Background: No previous study examined whether statins affect lymphocyte cytokine release in patients with isolated hypertriglyceridemia. Methods: The study included 46 patients with elevated triglyceride levels and peripheral artery stenosis, randomly assigned to receive simvastatin or placebo. Plasma lipids, glucose homeostasis markers, plasma C-reactive protein and lymphocyte cytokine release were measured at baseline and at the end of the treatment. Results: Ninety-day simvastatin treatment reduced lymphocyte release of TNF-α, interleukin-2 and interferon-γ, which was accompanied by a decrease in plasma C-reactive protein. Conclusion: The obtained results suggest that statins produce lymphocyte-suppressing and systemic anti-inflammatory effects in patients with isolated hypertriglyceridemia.
Authors and Affiliations
Robert Krysiak, Bogusław Okopień
Keywords
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